IndraLab

Statements

PI3K binds KCNH2 and PI3K_p85. 2 / 2
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"Furthermore, by sequestering the channel in the closed conformation, Cla inhibited the formation of a macromolecular complex between hERG1 and the p85 subunit of PI3K. This strongly reduced Akt phosphorylation, and stimulated the p53-dependent cell apoptosis, as witnessed by late caspase activation."
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sparser
"These data indicate that Cla affects the PI3K/Akt pathway by impairing the functional interaction between hERG1 and the p85 subunit of PI3K, and that these effects are different from those exerted by hERG1 blockers."
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