IndraLab

Statements

KMT5A methylates TP53 on K382. 18 / 18
1 | 12 5
sparser
"The direct functional link between Setd8 and p63 remains elusive but recent studies showed that Setd8 methylates p53 at lysine 382 and thereby suppresses p53-mediated transcription in vitro ( xref )."
22117221
reach
"We previously found that monomethylation of p53 at lysine 382 (p53K382me1) by the protein lysine methyltransferase (PKMT) SET8 and PR-Set 7 represses p53 transactivation of target genes."
20870725
sparser
"The methylation of p53 on lysine 382 by SET8 is suggested to inhibit transcription of a subset of target genes, such as the CDK inhibitors p21 and PUMA."
23345616
sparser
"As a methyltransferase, SET8 methylates lysine 382 of p53 to modulates p53 activity so as to change its transcriptional activity for downstream targets, furthermore, SET8 knockdown has been shown to upregulate cells’ sensitivity to cell death and cell cycle arrest following DNA damage by suppressing the biological function of p53 xref ."
27605386
reach
"We find that SET8 specifically monomethylates p53 at lysine 382 (p53K382me1)."
17707234
reach
"The p53 protein is also monomethylated at K382 (p53K382me1) by SET8."
23625014
sparser
"Additionally, SETD8 can induce the mono-methylation of the tumor suppressor p53 at lysine 382 (p53K382me1), which attenuates its pro-apoptotic and growth arrest functions [ xref , xref ]."
| PMC
biopax:pid
No evidence text available
17707234
reach
"We chose to inactivate the methyl-transferase SET8, which has been shown to mediate the inhibitory methylation of p53 at K382."
20598361
sparser
"Recently it has been shown that SET8 also methylates K382 in the p53 protein ."
22583696
reach
"Shi et al. showed that SET8 monomethylates p53 at K382 to inhibit its transcriptional activity and to consequently decrease expression of its target genes [XREF_BIBR]."
26305020
reach
"To test this idea, we used an siRNA to inhibit SET8, the monomethyl transferase that specifically methylates p53 at residue K382 (Shi et al., 2007)."
33961797
reach
"XREF_BIBR, XREF_BIBR The monomethylation of p53 at lysine 382 (p53K382me1) catalyzed by SETD8 suppresses p53 mediated transcription activation of highly responsive target genes."
25032507
reach
"[XREF_BIBR] SETD8 monomethylates protein P53 at lysine 382 and represses its proapoptotic and cell cycle arrest functions."
29657927
reach
"SET8 modulates p53 expression by methylating p53 at lysine 382."
24146953
reach
"The direct functional link between Setd8 and p63 remains elusive but recent studies showed that Setd8 methylates p53 at lysine 382 and thereby suppresses p53 mediated transcription in vitro."
22117221
reach
"243 The monomethylation of p53 (K382) by SETD8 represses p53 target genes."
28338320
reach
"39 SETD8 also monomethylates lysine 382 (K382) of the tumor suppressor p53 and lysine 248 (K248) of proliferating cell nuclear antigen (PCNA) and plays a potential role in human carcinogenesis."
25554733