IndraLab

Statements

CYLD leads to the ubiquitination of AKT. 3 / 3
| 3
reach
"Indeed, Cyld -/- MEFs displayed higher basal phosphorylation of Akt (at 0 min) and slightly enhanced IGF-1 mediated phosphorylation of Akt compared to wild-type MEFs (XREF_FIG), which correlated with the increased basal ubiquitination of Akt caused by Cyld deficiency (XREF_FIG)."
23300340
reach
"CYLD dissociated from Akt upon growth factor stimulation, thereby allowing E3 ligases to induce ubiquitination and activation of Akt."
23300340
reach
"We next determined whether CYLD deficiency promotes ubiquitination of endogenous Akt in response to IGF-1 stimulation."
23300340