IndraLab

Statements

OTUD3 binds PTEN. 24 / 25
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"miR-520h Regulates OTUD3-PTEN and Breast Cancer Progression."
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"To determine whether miR-520h expression and the OTUD3-PTEN axis are associated with the clinicopathological characteristics of breast cancer patients, 156 pairs of tumor tissues and adjacent normal tissues were analyzed by RT-PCR and immunohistochemistry (IHC)."
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"The expression change of OTUD3-PTEN signaling axis in glioma cells."
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"Finally, the interaction between OTUD3 and PTEN was not observed in lung cancer cells, and OTUD3 turned to interact with another substrate GRP78, a regulator which could promote tumorigenesis, metastasis and drug resistance in cancers xref – xref ."
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"Here we showed PTEN interacts with OTUD3 and influences stability of its downstream protein TOP2A, and this represents a novel mechanism by which PTEN regulates levels of its downstream targets."
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"We sought to determine which of these PTEN associated deubiquitinases associate with TOP2A, and found OTUD3 can associate with TOP2A. Co-IP assays confirmed interaction of PTEN and OTUD3 ( xref lane 3)."
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"In this study, we demonstrated that the mechanism through which miR-520h induces drug resistance involves the OTUD3-PTEN axis."
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"OTUD3 interacts with, de-polyubiquitylates and stabilizes PTEN."
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"miR-520h Targets OTUD3 and Suppresses OTUD3-PTEN Expression."
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"OTU domain-containing protein 3 (OTUD3) as one of the deubiquitinating enzymes from the OTU family has been reported to suppress the breast tumor via OTUD3-PTEN signaling axis ( xref )."
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"Here we showed PTEN interacts with OTUD3 and influences stability of its downstream protein TOP2A, and this represents a novel mechanism by which PTEN regulates levels of its downstream targets."
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No evidence text available
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"Co-IP assays confirmed interaction of PTEN and OTUD3 (XREF_FIG lane 3)."
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"Therefore, our findings showed that miR-520h targeted the OTUD3-PTEN axis to drive paclitaxel resistance, and this miR might be an important potential target for breast cancer treatment."
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"OTU domain-containing protein 3 (OTUD3), as a deubiquitinase (DUB) belonging to the ovarian tumor protease (OTU) family, has been reported to suppress tumor via OTUD3-PTEN signaling axis."
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"miR-520h Stimulates Drug Resistance to Paclitaxel by Targeting the OTUD3-PTEN Axis in Breast Cancer."
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"However, the role of the OTUD3-PTEN signaling axis in drug resistance and its relationship with miRNAs are unclear."
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"Recently, we identified the OTU (ovarian tumor protease) family member OTUD3 (OTU domain-containing protein 3) is a potential tumor suppressor gene in breast cancer and OTUD3 protein directly interacts with PTEN (phosphatase and tension homologue deleted in chromosome 10) and stabilizes PTEN protein to suppress PI3K/AKT signaling transduction xref ."
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"Studies have reported that downregulation of miR-520h contributes to anticancer activity in human breast cancer and human cervical cancer cell lines [ xref ]; miR-520h promotes drug resistance to paclitaxel by targeting OTUD3-PTEN axis in breast cancer [ xref ]; miR-520h overcomes bortezomib resistance in multiple myeloma via suppressing APE1 [ xref ]."
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"To explore the change of OTUD3-PTEN signaling axis, we detected the PTEN and OTUD3 protein levels in C6 cells and primary astrocytes ( xref )."
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"Our findings demonstrated that OTUD3 is an essential regulator of PTEN and that the OTUD3-PTEN signaling axis plays a critical role in tumor suppression."
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