IndraLab

Statements

PTEN binds OTUD3. 29 / 35
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"OTUD3 interacts with PTEN in the cytoplasm, deubiquitinates and stabilizes PTEN, ultimately inhibiting tumor growth and metastasis in breast cancer ( xref )."
37829187
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"OTUD3 interacts with PTEN, removing its polyubiquitination and promoting its stability."
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"Finally, the interaction between OTUD3 and PTEN was not observed in lung cancer cells, and OTUD3 turned to interact with another substrate GRP78, a regulator which could promote tumorigenesis, metastasis and drug resistance in cancers xref – xref ."
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"Here we showed PTEN interacts with OTUD3 and influences stability of its downstream protein TOP2A, and this represents a novel mechanism by which PTEN regulates levels of its downstream targets."
26657567
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"Early evidence suggests that OTUD3 functions as a deubiquitinase for PTEN, interacting with PTEN to enhance its stability, thus inhibiting the progression of breast cancer [ xref ]."
39097608
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"Studies have reported that downregulation of miR-520h contributes to anticancer activity in human breast cancer and human cervical cancer cell lines [ xref ]; miR-520h promotes drug resistance to paclitaxel by targeting OTUD3-PTEN axis in breast cancer [ xref ]; miR-520h overcomes bortezomib resistance in multiple myeloma via suppressing APE1 [ xref ]."
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"OTUD3 interacts with PTEN in the cytoplasm, deubiquitinates and stabilizes PTEN, ultimately inhibiting tumor growth and metastasis in breast cancer (Yuan et al., 2015)."
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"OTUD3 interacts with, de-polyubiquitylates and stabilizes PTEN."
26280536
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"Similarly, the deubiquitylase OTUD3 can interact with PTEN and deubiquitinate it, thus stabilising PTEN and inhibiting the development of breast cancer ( xref )."
36969062
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"OTUD3 (OTU region) directly interacts with PTEN (C2 domain), deubiquitinating and stabilizing the PTEN protein to suppress PI3K-AKT signaling xref ."
36385557
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"We sought to determine which of these PTEN associated deubiquitinases associate with TOP2A, and found OTUD3 can associate with TOP2A. Co-IP assays confirmed interaction of PTEN and OTUD3 ( xref lane 3)."
26657567
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"Recently, we identified the OTU (ovarian tumor protease) family member OTUD3 (OTU domain-containing protein 3) is a potential tumor suppressor gene in breast cancer and OTUD3 protein directly interacts with PTEN (phosphatase and tension homologue deleted in chromosome 10) and stabilizes PTEN protein to suppress PI3K/AKT signaling transduction xref ."
31266968
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"Therefore, our findings showed that miR-520h targeted the OTUD3-PTEN axis to drive paclitaxel resistance, and this miR might be an important potential target for breast cancer treatment."
32775453
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"Our findings demonstrated that OTUD3 is an essential regulator of PTEN and that the OTUD3-PTEN signaling axis plays a critical role in tumor suppression."
32775453
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"However, the role of the OTUD3-PTEN signaling axis in drug resistance and its relationship with miRNAs are unclear."
32775453
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"miR-520h Targets OTUD3 and Suppresses OTUD3-PTEN Expression."
32775453
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"miR-520h Regulates OTUD3-PTEN and Breast Cancer Progression."
32775453
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"To determine whether miR-520h expression and the OTUD3-PTEN axis are associated with the clinicopathological characteristics of breast cancer patients, 156 pairs of tumor tissues and adjacent normal tissues were analyzed by RT-PCR and immunohistochemistry (IHC)."
32775453
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"Several studies have demonstrated that OTUD3 interacts with PTEN and induces its deubiquitination, increasing PTEN protein stability and inhibiting carcinogenic PI3K/AKT signaling ( xref )."
40337608
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"In this study, we demonstrated that the mechanism through which miR-520h induces drug resistance involves the OTUD3-PTEN axis."
32775453
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"Here we showed PTEN interacts with OTUD3 and influences stability of its downstream protein TOP2A, and this represents a novel mechanism by which PTEN regulates levels of its downstream targets."
26657567
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"miR-520h stimulates PTX resistance by targeting the OTUD3-PTEN axis in BC cells[ xref ]."
37842231
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"OTU domain-containing protein 3 (OTUD3), as a deubiquitinase (DUB) belonging to the ovarian tumor protease (OTU) family, has been reported to suppress tumor via OTUD3-PTEN signaling axis."
32395534
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"OTU domain-containing protein 3 (OTUD3) as one of the deubiquitinating enzymes from the OTU family has been reported to suppress the breast tumor via OTUD3-PTEN signaling axis ( xref )."
32395534
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"To explore the change of OTUD3-PTEN signaling axis, we detected the PTEN and OTUD3 protein levels in C6 cells and primary astrocytes ( xref )."
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"It has been reported that the deubiquitinating enzyme family OTUD3 can directly interact with the tumor suppressor protein PTEN and stabilize PTEN through deubiquitination modification, thereby antagonizing the PI3K-AKT signaling pathway and exerting a tumor suppressor function (Yuan et al., 2015; ZhEl-Kott et al., 2020)."
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"Co-IP assays confirmed interaction of PTEN and OTUD3 (XREF_FIG lane 3)."
26657567
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"Thus, the OTUD3-PTEN axis could be a promising target for cancer prevention and treatment [ xref , xref ]."
39144161
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"It has been reported that the deubiquitinating enzyme family OTUD3 can directly interact with the tumor suppressor protein PTEN and stabilize PTEN through deubiquitination modification, thereby antagonizing the PI3K-AKT signaling pathway and exerting a tumor suppressor function ( xref ; xref )."
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