IndraLab

Statements

Modified ESR2 decreases the amount of ESR1. 8 / 8
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"Knockdown of ESR2 in endometriotic stromal cells increased the expression of ESR1 twofold, and overexpression of ESR2 in endometrial stromal cells reduced the expression of ESR1 by one-half [XREF_BIBR, XREF_BIBR]."
30728052
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"In the normal breast, ERbeta is more abundant than is ERalpha; recent data suggest that high levels of ERbeta can down-regulate the expression of ERalpha XREF_BIBR."
25405629
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"High levels of ERbeta suppress ERalpha expression."
22772552
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"The same group demonstrates increased ERbeta levels concomitant with lower ERalpha levels in endometriosis and experimentally demonstrates that knockdown of ERbeta increases ERalpha while overexpression of ERbeta decreases ERalpha levels."
22648069
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"In summary, high levels of ERbeta suppress ERalpha expression and response to estradiol in endometriotic stromal cells via binding to nonclassic DNA motifs in alternatively used ERalpha promoters."
20104427
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"High levels of ERbeta suppress ERalpha expression and response to estradiol in endometrial and endometriotic stromal cells via binding to classic and nonclassic DNA motifs in alternatively used ERalpha promoters."
19001520
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"Our results showed that the over-expression of ERbeta in GH3 reduced the baseline ERalpha expression, with E2, PPT or DPN stimuli being unable to modify its expression."
26282612
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"This increase may be mediated by an increased presence of TEB in the mammary epithelial tree and increased ER-alpha levels, reduced ER-beta levels or both."
11208953