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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

HDAC decreases the amount of TSC2. 2 / 2

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"This report is a first step at defining underlying events, uncovering a mechanism of HDAC dependent repression of TSC2 expression, resulting in the release of active mTOR."

27048565

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"Class I HDAC inhibition in the heart was shown to promote expression of tuberous sclerosis complex 2 (TSC2), which is an inhibitor of pro hypertrophic mechanistic target of rapamycin (mTOR) kinase signaling [XREF_BIBR]."

28886967

Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...