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COPS5 increases the amount of CTNNB1. 16 / 16
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"2A-D, PDIA6 or CSN5 knockdown significantly reduced β-catenin protein levels and activity but increased its phosphorylated form in the DMSO-treated cells."
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"Recent studies have revealed that JAB1 knockdown downregulates total β-catenin expression in human CRC cells [ 7 ], and JAB1 overexpression enhances the degradation of SIAH-1, a putative E3 ubiquitin [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Next, we examined the role of JAB1 in the expression of nuclear β-catenin, the main driving force for the tumorigenesis of CRC, and found that JAB1 knockdown significantly decreased nuclear β-catenin [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"The mechanistic basis for this effect is intriguing but currently fully unclear and will have to be the subject of future studies, with counter-regulatory effects on alternative β-catenin degradation [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"As presented in Fig. 9A, CSN5 overexpression decreased the phosphorylation of β-catenin but increased β-catenin and PD-L1 levels."
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"Since JAB1 knockdown significantly decreased nuclear JAB1 expression, but not clearly decrease cytoplasmic JAB1 expression, the decrease in nuclear JAB1 expression may cause the decrease in nuclear β-[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"We have previously demonstrated that CSN5 knockdown leads to decreased beta-catenin levels in CRC cell lines, thereby diminishing WNT signaling activity [27,28]."
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"Meanwhile, our data indicate that knockdown of CSN5 dramatically increased the levels of β-catenin ubiquitination, while overexpression of SAPG5 significantly decrease the levels of β-catenin ubiquitination (Fig. 6o)."
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"These results support the hypothesis that nuclear JAB1 positively regulates nuclear β-catenin expression."
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"There are two possible mechanism by which JAB1 positively regulates nuclear β-catenin expression."
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"In addition, Jab1/CSN5 positively regulates the expression of β-catenin via the E3 ubiquitin ligase SIAH-1 ."
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"Together, these experiments indicated that SIAH-1 promotes beta-catenin degradation in HCT116 cells.The data so far suggested that a CSN5 knockdown attenuates beta-catenin levels and Wnt and beta-cate[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"These findings suggest that JAB1 induces the expression of JAB1 itself in addition to β-catenin/TCF4 and STAT3 targets including c-MYC.In conclusion, we have demonstrated that JAB1 positively regulate[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"We previously showed that CSN5 and JAB1 increases total beta-catenin levels while it also promotes the short-term proteasomal degradation of beta-catenin in SW480 CRC cells [30]."
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"Furthermore, JAB1 positively regulates the expression of total β-catenin [ 7 ] and enhances the degradation of seven in absentia homolog-1 (SIAH-1), a putative E3 ubiquitin ligase of β-catenin, in hum[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"These results suggest that JAB1 positively regulates the expression of nuclear β-catenin and c-MYC as a β-catenin/TCF4 target in COLO-320 cells.Next, to elucidate the role of JAB1 in cell cycle regula[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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