IndraLab

Statements

COPS5 increases the amount of CTNNB1. 6 / 6
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"In this study, we have demonstrated that JAB1 positively regulates the expression of nuclear beta-catenin, c-MYC as a beta-catenin and TCF4 target, and cell cycle regulators, such as Ki-67 and topoisomerase IIalpha, in human CRC cells."
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"Meanwhile, our data indicate that knockdown of CSN5 dramatically increased the levels of β-catenin ubiquitination, while overexpression of SAPG5 significantly decrease the levels of β-catenin ubiquitination (Fig. 6o)."
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"Together, these experiments indicated that SIAH-1 promotes beta-catenin degradation in HCT116 cells.The data so far suggested that a CSN5 knockdown attenuates beta-catenin levels and Wnt and beta-cate[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"We have previously demonstrated that CSN5 knockdown leads to decreased beta-catenin levels in CRC cell lines, thereby diminishing WNT signaling activity [27,28]."
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"We previously showed that CSN5 and JAB1 increases total beta-catenin levels while it also promotes the short-term proteasomal degradation of beta-catenin in SW480 CRC cells [30]."
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"Recent studies reveal that Jun activation domain binding protein 1 (JAB1) enhances the degradation of seven in absentia homolog-1 (SIAH-1), a putative E3 ubiquitin ligase of beta-catenin, and positively regulates the expression of total beta-catenin in human CRC cells."
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