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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

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Statements

OTUB2 increases the amount of BMP2. 2 / 2

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"We also found that OTUB2 knockdown suppressed the ALP activity and the expression of the common markers BMP2 and RUNX2 during osteogenesis of MSCs in response to Shh and Smo agonists, which indicated OTUB2 may have effect on osteogenic differentiation by regulating Hh signaling."

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"OTUB2 knockdown suppressed the alkaline phosphatase activity and the expression of the common osteogenic markers BMP2 and RUNX2 during osteogenesis of mesenchymal stem cells in response to Shh and Smo agonists, suggesting that OTUB2 may play a role in osteogenic differentiation by regulating Hh signaling [64]."

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INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...