IndraLab

Statements

EGFR phosphorylates PLCG1 on tyrosine. 11 / 11
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rlimsp
"In the present study we demonstrated that BPQs not only induced EGFR tyrosine autophosphorylation, but also induced EGFR-dependent tyrosine phosphorylation of phospholipase C-gamma1 and several signal transducers and activators of transcription (STATs)."
19166869
rlimsp
"Tyrosine phosphorylation of phospholipase C-II in vitro by the epidermal growth factor receptor."
2732223
reach
"Based on our results, EGFR cleavage by caspase-3 results in defective tyrosine phosphorylation of PLC-gamma1."
11226410
reach
"Phosphorylation of phospholipase C-gamma 1 by the epidermal growth factor receptor tyrosine kinase overcomes the inhibitory effect of profilin and results in an effective activation of phospholipase C-gamma 1."
1848725
reach
"Tyrosine phosphorylation of PLC-gamma1 by the EGF receptor is crucial for the enzymatic activation of PLC-gamma1 [21,26]."
11226408
sparser
"The EGFR phosphorylates PLCγ1 on the tyrosine residues 771, 783, and 1253 leading to increased enzymatic activation [8] ."
17561374
reach
"Then, the EGFR phosphorylates PLCgamma1 on several tyrosine residues (771, 783 and 1253) leading to increased enzymatic activation [13,14]."
20965248
reach
"In this communication we demonstrate that PLC-II (Mr = 145,000) purified from bovine brain can be phosphorylated in vitro in an EGF dependent manner by the tyrosine kinase activity of the purified EGF receptor."
2732223
sparser
"Then, the EGFR phosphorylates PLCγ1 on several tyrosine residues (771, 783 and 1253) leading to increased enzymatic activation [13,14] ."
20965248
rlimsp
"Binding of EGF to cells expressing human EGF receptor stimulated rapid tyrosine phosphorylation of phospholipase C-II (PLC-II), as revealed by immunoblotting analysis with phosphotyrosine-specific antibodies."
2472218
reach
"Both the wt-EGFR and EIR-2 show a rapid increase in tyrosine phosphorylation of PLC-gamma1, within 5 min of hormone addition."
10350617