IndraLab

Statements

PTEN activates TP53. 84 / 95
| 1 1 78 4
reach
"Meanwhile, TMOC up-regulated the expression levels of PTEN in all of the three cell lines, but only up-regulated p53 in A2780 cells."
25180593
reach
"Second, PTEN can also compete with MDM2 binding, and thereby block p53 degradation [22,23]."
21664656
reach
"A contrasting role is observed in CML and B cell lineage (B-ALL)-like leukemia, where PTEN causes FOXO dependent upregulation of p53 suppressor Bcl6, allowing ALL and CML cells to escape p53- and p21 mediated cellular senescence [XREF_BIBR]."
33396222
reach
"Nuclear PTEN, independent of its phosphatase activity, leads to p53 mediated G (1) growth arrest, cell death, and reduction of reactive oxygen species production."
18332125
reach
"Importantly, elevated serum HBsAg and ALT levels were seen in HBV transgenic mouse following sgp53 and Pten dual cassette induced p53 and Pten deficiency in mouse livers."
28584302
reach
"Inactivation of Pten in the prostate of mice induces the onset of precancerous high-grade prostatic intraepithelial neoplasia (HG-PIN) and p53 dependent senescence XREF_BIBR."
23139867
reach
"PTEN plays an important role in regulating p53 protein levels and activity; loss of PTEN may decrease the selective pressure on tumors to lose p53 during cancer progression.In an attempt to further de[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12620407
reach
"We revealed that the downregulation of p21 is necessary for apoptosis induction and PTEN promotes apoptosis by amplifying p53 activation."
24260342
reach
"As discussed above, activation of PI3K (Pten)-Akt activates p53 and activated p53 inhibit PI3K (Pten)-Akt (XREF_FIG)."
25486431
reach
"This study provides evidence that PTEN can modulate p53 function independently of its phosphatase activity, and that a physical interaction between PTEN and p53 is important for this modulation in viv[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12620407
reach
"Additionally, p53 -pAkt and p53 -pFOXO3 complexes measured by PLA were diminished by KD of p53, PIPKIα, or IPMK, but enhanced by PTEN KD under basal and stressed conditions (Fig. 5f,g and Extended Data Fig. 5o,p)."
35798843
reach
"However, PTEN activates p53 and sensitizes tumor cells to chemotherapy by retaining MDM2 in the cytoplasm (Mayo et al., 2002)."
34869377
sparser
"Several studies have demonstrated that PTEN can activate p53 through direct and indirect protein–protein interactions, including phosphatase-dependent and phosphatase-independent mechanisms. xref , xref With all of these observations, we propose a model for the action of progesterone in ER/PR-positive breast cancer via PR in a time- and concentration-dependent manner by modulating signaling pathways that include tumor suppressor pathways ( xref )."
26609221
reach
"Such an arrest correlated with down-regulation of cyclins and CDKs and up-regulation of the CDK inhibitor p21 and p27 expression, whereas up-regulation of p53 by PTEN expression was not observed."
14984207
reach
"On the other hand, PTEN is a transcriptional target of p53 and a mediator of p53 triggered apoptosis."
21420949
reach
"Several studies have demonstrated that PTEN can activate p53 through direct and indirect protein protein interactions, including phosphatase dependent and phosphatase independent mechanisms."
26609221
reach
"However, systemic p19 ARF deficiency in Pten pc-/- mice did not accelerate PCa or enhance p53 accumulation XREF_BIBR, which might be explained by inflammatory cytokines and/or growth factors produced by the multiple tumours developing in other organs XREF_BIBR."
26198641
reach
"Nuclear PTEN function leads to p53 mediated G (1) growth arrest, cell death, and reduction of reactive oxygen species production [XREF_BIBR]."
20626841
reach
"In particular, PTEN loss decreases Chk1 and p53 activity by regulating their protein levels and promoting genomic instability in tumor cells XREF_BIBR, XREF_BIBR."
29581786
reach
"Two explanations may account for this result : first, PTEN may dissociate from the p53 and DNA complex during the electrophoresis; second, PTEN may induce a conformational change of latent p53 and dis[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12620407
reach
"MUTYH, PTEN, RB1, TP53, and TSC1 (XREF_TABLE) genes were found to be commonly mutated in these two cell lines, supporting the proposed role of TP53, PTEN, and RB1 in the pathogenesis of human glioblastomas."
33390879
reach
"Overexpression of PTEN showed inhibition of Akt activation, further supporting the idea that PTEN upregulates p53 through the Akt pathway, and how it might be involved in cell- cycle arrest and apoptosis in CR ovarian cancer cells."
23663277
reach
"The tumor suppressor PTEN can lead to activation of p53 through the downregulation of Mdm2 [XREF_BIBR, XREF_BIBR, XREF_BIBR]."
27898034
reach
"PTEN promotes p53 activity and regulates cellular levels of MDM2."
18363844
eidos
"HOXA5 is controlled by DNA methylation [ 48 ] , and has been shown to up-regulate the tumor suppressor p53 and AKT1 by down-regulation of PTEN [ 49 ] ."
30442871
reach
"Alternatively, PTEN can increase p53 protein stability and its transcriptional activity, which is dependent on the physical association between PTEN and p53 but independent of the PI3K-AKT pathway [XREF_BIBR]."
28602818
reach
"Wildtype p53 is a recognized regulator of PTEN transcription, and PTEN acts to prevent degradation of p53 by MDM2 [XREF_BIBR, XREF_BIBR]."
29416795
reach
"SsnB treatment induced PTEN expression increased p53, p21 upregulation and decreased hedgehog signaling in liver."
30194936
reach
"PTEN in the nucleus has been shown to promote the stability and transcriptional activity of the tumor suppressor p53 by directly associating with p53 [XREF_BIBR - XREF_BIBR]."
23853672
reach
"Next, we will investigate how miR-192 and PTEN contribute to p53-dependent apoptosis.The bifurcation diagram of [p53∗] versus DD is plotted for different miR-192 and PTEN expression states (Figure 9A)."
31561425
reach
"We further show that PTEN enhances p53 transactivation, a relationship that requires the interaction between PTEN and p53 and is PTEN phosphatase independent."
16424003
reach
"Loss of one copy of the PTEN gene strongly predisposes to cancer development [XREF_BIBR], while complete PTEN loss can lead to a p53 dependent cellular senescence response [XREF_BIBR]."
23503512
sparser
"Several studies have demonstrated that PTEN can activate p53 through direct and indirect protein-protein interactions, including phosphatase-dependent and -independent mechanisms ( xref – xref )."
18767981
reach
"We next sought to determine whether the sgp53 and Pten dual cassette induced direct genome editing of p53 and Pten genes in liver tumors."
28584302
reach
"MSeA treatment of the Pten KO mice dramatically increased P53 and P21Cip1, but this did not occur in WT mice, while p-Akt expression was not affected in MSeA treated KO or WT mice (XREF_FIG)."
26511486
reach
"Thus, complete loss of PTEN results in an indolent prostate cancer, due to the fact that PTEN inactivation in the prostate triggers a p53 cellular senescence response in vivo, thereby limiting the progression of cancer."
20174572
reach
"The PTEN stimulated p53 and DNA complex could be supershifted by the addition of anti-p53 antibody but not by the addition of anti-PTEN antibody, suggesting that PTEN may not be a part of the p53 and [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12620407
reach
"In response to injury, the inhibition of PTEN activity suppressed the activation of the p53 signaling pathway, resulting in inflammatory cell infiltration and proinflammatory molecule production and cell apoptosis."
29262553
reach
"We confirmed the interactions of IPMK and PTEN with stress-induced p53 and mutant p53 by co-IP (Fig. 4f, g and Extended Data Fig. 3i)."
35798843
reach
"PTEN mediated repression requires its lipid phosphatase activity and is independent of the p53 status of the cell."
16055704
reach
"It has been reported that PTEN deficiency can activate p53."
24561254
reach
"Nuclear PTEN, independent of its phosphatase activity, leads to p53 mediated G1 growth arrest, cell death, and reduction of reactive oxygen species production."
27493922
reach
"We hypothesize that the association of PTEN with the C-terminal negative-regulatory domain of p53 may trigger a conformational change in the p53 molecule, thereby preventing MDM2 binding, although we [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12620407
reach
"PTEN can inhibit Akt, thereby affecting the subcellular localization of MDM2, (ii) PTEN can downregulate MDM2 and increase p53 stability [63], (iii) PTEN is a transcriptional target of p53 [64], sugge[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
16697215
reach
"Whether PTEN induced p53 protein stability to upregulate BTG2 gene expression in bladder carcinoma cells needs further investigation."
29239139
reach
"Nuclear PTEN leads to p53 mediated G1 growth arrest, suggesting that nuclear PTEN plays a unique role in arresting and protecting cells upon oxidative damage and a cooperative role with p53 in tumor suppression [XREF_BIBR]."
22266095
reach
"Accumulating evidence is beginning to suggest that, in certain circumstances, PTEN (phosphatase and tensin homologue deleted on chromosome 10)/PI3K/Akt also promotes p53 translation and protein stability, suggesting that additional mechanisms may be involved in the Akt mediated regulation of p53 in tumours."
25109960
reach
"In the nucleus, PTEN may promote p53 stability and transcriptional activity by directly associating with p53."
18950730
reach
"Further investigation revealed that loss of PTEN activated Akt and HDM2 and promoted degradation of p53, which attributes to resistance of CCRCC cell apoptosis induced by etoposide."
25954860
reach
"PTEN had been shown to inhibit movement of Mdm2 into the nucleus and thereby inhibited p53 proteasomal degradation, rendering cells susceptible for apoptosis inducing stimuli."
12740039
trips
"We further show that PTEN enhances p53 transactivation, a relationship that requires the interaction between PTEN and p53 and is PTEN phosphatase independent."
16424003
reach
"We anticipated that expression of PTEN would up-regulate p53 activity and have an inverse effect on MDM2 levels."
18363844
reach
"Retroviral transduction of PTEN into PTEN null glioblastoma cells increases p53 activity and expression of p53 target genes and induces cell cycle arrest [XREF_BIBR]."
19384426
reach
"The sgp53 and Pten dual cassette induced high frequency of p53 and Pten mutation in the tumors of HBV transgenic mice."
28584302
reach
"Mutations in PIK3CA or PTEN genes may decrease the gene expression level of TP53 tumor suppressor through AKT and MDM2 cascade."
26810975
reach
"For severe damage, PTEN is induced to drive p53 to high levels, leading to its full activation."
24260342
sparser
"However, PTEN activates p53 and sensitizes tumor cells to chemotherapy by retaining MDM2 in the cytoplasm (Mayo et al., 2002)."
34869377
reach
"Furthermore, PTEN expression could partially prevent p53 degradation caused by overexpression of MDM2."
12620407
reach
"Several studies have demonstrated that PTEN can activate p53 through direct and indirect protein protein interactions, including phosphatase dependent and -independent mechanisms."
18767981
reach
"Furthermore, NPTX2 enhanced the protein expression of p53, p21 and PTEN to activate the p53 signaling pathway."
33896384
reach
"In addition, anti4534 mediated induction of PTEN decreased downstream pAkt and induced p21, p53 and p73 that are involved in cell survival, apoptosis, proliferation, growth, migration and angiogenesis [XREF_BIBR, XREF_BIBR, XREF_BIBR - XREF_BIBR]."
27634912
reach
"Accordingly, combined inactivation of Pten and Tp53 induce glioblastoma, which was achieved through GFAP-CreER; Pten loxP and loxP; Tp53 loxP and loxP compound mice, hereafter termed Pten; p53 cKO mice."
28368413
reach
"We found that Pten C terminal disruption induces p53 and its downstream targets."
24561254
reach
"For example, PTEN promotes p53 transactivity using its canonical lipid phosphatase activity likely by suppressing AKT dependent phosphorylation and nuclear translocation of MDM2, a major negative regulator of p53 [XREF_BIBR]."
28602818
reach
"Further, p53 degradation is reduced indirectly by PTEN via its antagonism of PI3K [XREF_BIBR, XREF_BIBR]."
21317449
reach
"Retroviral transduction of PTEN into U87MG (PTEN null) glioblastoma cells increases p53 activity and expression of p53 target genes and induces cell cycle arrest."
11729185
reach
"In the nucleus, PTEN, the negative regulator of PI-3-K, may promote p53 stability and transcriptional activity by directly associating with p53 [65]."
19720099
reach
"In summary, employing the CHME5 model system, we observed that HIV-1 Tat expression induces (1) a decrease in PTEN level, (2) a decrease of p53 function and (3) an increase of E2F function, which coll[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
17157319
reach
"In the nucleus, PTEN promotes the stability and transcriptional activity of the tumor suppressor p53 by directly associating with p53."
30038596
reach
"In fact, downregulation of Pten may be a prerequisite to Myc driven oncogenesis, since elevated and prolonged Myc expression can induce apoptosis, potentially via Pten activation of p53 and Rad51."
24199173
reach
"How PTEN modulates p53 half-life in the absence of MDM2 is currently unknown and is worth further investigation."
12620407
reach
"PTEN also increases the transcriptional activity of wt p53 through physical interaction."
26858938
reach
"Recently, PTEN has been shown to induce gain-of-function p53 protein suggesting that TZD treatment in this setting may subsequently induce mutant, nonbeneficial p53 protein."
19096712
reach
"Recent studies have indicated that PTEN WT enhances p53 mediated transactivation of the promoter by stabilization of p53 in a phosphatase independent manner."
20926450
reach
"44 Importantly, acute PTEN inactivation triggers p53 dependent cellular senescence as a checkpoint to restrain tumorigenesis."
19625770
reach
"Additionally, XREF_BIBR demonstrated that the ability of PTEN to inhibit tRNALeu transcription is independent of p53, we speculate that PTEN mediated inhibition of U6 snRNA transcription in HCC1937 cells may also be independent of p53 as HCC1937 cells are p53 null."
21479160
reach
"XREF_BIBR, XREF_BIBR Under oxidative stress, PTEN accumulated in the nucleus increases p53 function that prevents genotoxicity and tumor growth."
24858043
reach
"PTEN can directly or indirectly activate p53 to promote apoptosis."
21873427
reach
"P53 protein levels are significantly reduced in Pten heterozygous ES cells and almost completely lost in Pten null ES cells, while these ES cells do express similar levels of p53 mRNA, suggesting that[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12620407
reach
"Inactivation of p53 signaling by p73 or PTEN ablation results in a transformed phenotype that remains susceptible to Nutlin-3 mediated apoptosis."
20305378
sparser
"PTEN can directly or indirectly activate p53 to promote apoptosis."
21873427
reach
"Moreover, the inhibition of P-PTEN by Pokemon most likely downregulates p53 mediated functions, consequently promoting the progression of HCC."
23300578
reach
"Beyond its cytoplasmic role in negatively regulating PI3K and AKT, PTEN is phosphorylated and accumulated in the nucleus in response to the Spry2 deficiency to induce p53 mediated growth arrest independently of its phosphatase activity [XREF_BIBR]."
24744103
reach
"p53 protein (P53) significantly, but slightly increased during antibody treatment, because PTEN expression increased the stability and function of P53 via both molecular interactions."
28498467