IndraLab

Statements

Pyraclofos activates HCN4. 17 / 17
| 9 8
reach
"The voltage dependent activation of HCN2 and HCN4 has been studied in HEK293 cells and different values for midpoint activation of HCN2 and HCN4 have been reported [XREF_BIBR - XREF_BIBR]."
19236845
sparser
"To test whether this hyperpolarized potential influences voltage-dependent activation of HCN4 channels, we recorded steady-state activation curves from different holding potentials (HP) corresponding to membrane potentials during the firing (−55 mV) and nonfiring mode (−65 and −75 mV)."
33144559
reach
"LRMP and IRAG were identified following an initial observation that the voltage-dependent activation of HCN4 is shifted to more depolarized potentials in a cAMP-independent manner and is not shifted further by exogenous cAMP when the channels are expressed in Chinese hamster ovary (CHO) cells (Liao et al., 2012)."
35795651
reach
"Binding here places CBD close to the charged residues of the voltage sensor (Fig. 5), a prime position from which to regulate HCN4 activation voltage dependence."
38652080
sparser
"Voltage activation of HCN4 is most dramatically depolarized by the presence of cAMP, whereas HCN1 is minimally cAMP-reponsive."
21130878
sparser
"LRMP and IRAG were identified following an initial observation that the voltage-dependent activation of HCN4 is shifted to more depolarized potentials in a cAMP-independent manner and is not shifted further by exogenous cAMP when the channels are expressed in Chinese hamster ovary (CHO) cells ( xref )."
35795651
reach
"Since CBD potentiates HCN4 channels by shifting voltage dependence and speeding activation, it must contain novel features or functional groups compared with these three plant metabolites.HCN channels have been found to be regulated by a variety of human-derived lipids, including phosphoinositides (Pian et al, 2006, 2007; Zolles et al, 2006; Flynn and Zagotta, 2011)."
38652080
reach
"Voltage activation of HCN4 is most dramatically depolarized by the presence of cAMP, whereas HCN1 is minimally cAMP-reponsive."
21130878
reach
"According to the concept of hysteresis, voltage-dependent activation of HCN4 is a history-dependent process, i.e., the position of the activation curve on the voltage axis (x-axis) is determined by long-lasting membrane potentials (Fig. 2B, C)."
35556164
sparser
"This shift would be smaller at voltages activating only HCN1 and larger at voltages which activate HCN4."
21456027
reach
"This positive effect of temperature on voltage-dependent activation of I and the HCN4 channel is anticipated by the activation kinetics of the currents that appears faster at higher temperature (e.g., Fig. 2a, b)."
40025061
sparser
"As quantified in Fig.  xref , cAMP shifted voltage-dependent activation of both wild-type HCN4 and variant HCN4 V759I channels to the same extent, that is by 10.3 ± 1 mV ( n  = 8) and 10.0 ± 0.9 mV ( n  = 8), respectively, starting from insignificantly different activation voltages prior cAMP application (values for V 1/2 of − 128.0 ± 3.7 mV and − 135.3 ± 2.5 mV for wild-type and variant HCN4, respectively, n  = 8)."
33095298
reach
"As part of our ongoing studies of HCN4 channel regulation, we set out to describe the effects of cAMP on the voltage dependent activation of full-length mouse HCN4 channels."
23109717
sparser
"From the observations described above we have therefore derived the hypothesis that the voltage-dependent activation of HCN4 shifts dynamically as a function of the membrane potential and that the hal[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
33753086
sparser
"Voltage-dependent activation of HCN4 is therefore a dynamic and history-dependent process xref – xref ."
33144559
reach
"From the observations described above we have therefore derived the hypothesis that the voltage-dependent activation of HCN4 shifts dynamically as a function of the membrane potential and that the hal[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
33753086
sparser
"According to the concept of hysteresis, voltage-dependent activation of HCN4 is a history-dependent process, i.e., the position of the activation curve on the voltage axis ( x -axis) is determined by long-lasting membrane potentials (Fig.  xref , xref )."
35556164