IndraLab

Statements

KCNK2 binds PLD2. 4 / 4
| 4
sparser
"Early TREK-1 studies[ xref , xref , xref ] were unaware of PLD2 mechano and anesthetic sensitivity [ xref , xref ] and the direct interaction of PLD2 with TREK-1[ xref ]."
31672538
sparser
"PA and PG are both products of the enzyme PLD2 ( xref ), and we expect these lipids to agonize the channel as PLD2 binds directly to the C terminus of TREK-1 and activates the channel ( xref ) (see also xref )."
28793254
sparser
"In addition to binding PIP 2 , PLD2 also binds directly to the C-terminus of TREK-1 and activates the channel through local production of phosphatidic acid [ xref , xref ], presumably in the disordered region of the cell membrane [ xref ]."
31672538
sparser
"PA appears to activate TREK-1 as phospholipase D2 (PLD2) directly binds to TREK-1 and activates the channel through local production of lipid ( xref )."
28793254