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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

KCNQ5 inhibits calcium(2+). 2 / 2

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"The resulting outward K + current opposes membrane depolarization and prevents E m from reaching the threshold for triggering action potential firing; (2) Suppression of KCNQ5 channel activity by physiological concentrations of AVP will depolarize the membrane and stimulate Ca 2+ influx though voltage sensitive Ca 2+ channels; (3) Activation of TRPC6 non selective cation currents modestly contributes to AVP induced membrane depolarization and generation of Ca 2+ spikes at physiological concentrations of AVP."

19246091

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"KCNQ5 knockdown resulted in more positive resting membrane potentials and induced spontaneous action potential firing and Ca 2+ spiking."

19246091

Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...