IndraLab

Statements

MEK binds BRAF and RAF1. 6 / 6
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"EGF stimulation strongly promoted formation of the MEK-BRAF-CRAF complex within 5 min, followed by a gradual return to low basal levels of interaction after 30–60 min."
33568355
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"In case of the MAPK pathway, RKIP was shown to bind B-Raf and c-Raf as well as MEK and thereby inhibiting the Raf/MEK interaction [ xref ]; in case of the NFκB pathway, NFκB-inducing kinase and transforming growth factor beta-activated kinase-1 are the targets."
17958888
sparser
"Indeed, we found that expression of KRAS G12C promotes RAS-RAF dimer formation without influencing BRAF-CRAF and BRAF-MEK binding, suggesting that RAS is joining a multimeric complex ( xref )."
25127139
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"While the results varied somewhat between the groups, the BRAF inhibitors promoted the formation of heterodimers of BRAF and CRAF that potently activate MEK in cells without a BRAF mutation."
21111965
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"We therefore used surface plasmon resonance (SPR) analyses to assess whether CH5126766 binds directly to MEK, BRAF, or CRAF."
23667175
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"Thus, to gain insight into these BRAF conformations, we used the formation of the MEK-BRAF-CRAF signaling complex during growth factor-induced MAPK activation, to indirectly monitor the conformation of full-length BRAF as a function of its activation in the native state."
33568355