A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.



phosphosite cbn pc11 biopax bel_lc signor biogrid tas lincs_drug hprd trrust | geneways tees isi trips rlimsp medscan sparser reach

MEK binds BRAF and RAF1. 4 / 4
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"While the results varied somewhat between the groups, the BRAF inhibitors promoted the formation of heterodimers of BRAF and CRAF that potently activate MEK in cells without a BRAF mutation."
"We therefore used surface plasmon resonance (SPR) analyses to assess whether CH5126766 binds directly to MEK, BRAF, or CRAF."
"In case of the MAPK pathway, RKIP was shown to bind B-Raf and c-Raf as well as MEK and thereby inhibiting the Raf/MEK interaction [ xref ]; in case of the NFκB pathway, NFκB-inducing kinase and transforming growth factor beta-activated kinase-1 are the targets."
"Indeed, we found that expression of KRAS G12C promotes RAS-RAF dimer formation without influencing BRAF-CRAF and BRAF-MEK binding, suggesting that RAS is joining a multimeric complex ( xref )."