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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

KCNQ2 activates dopamine. 2 / 2

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"Kcnq2 and Kcnq3 have been shown to mediate the release of dopamine after exposure to ethanol."

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"Our current results demonstrate that: (1) CCI differentially modulated the firing activity of the VTA-to-NAc and VTA-to-mPFC DA circuits, and of the two, the former is involved in thermal nociception regulation; (2) both KCNQ2 overexpression in the VTA-to-NAc DA neurons and intra-VTA injection of the KCNQ opener retigabine corrected mesolimbic KCNQ channel-mediated M-currents and DA neuronal activity, and relieved CCI-induced thermal nociception; and (3) BDNF signaling in the VTA-to-NAc DA circuit may be involved in the anti-nociceptive effect of retigabine."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...