IndraLab

Statements

KCNQ2 activates dopamine. 3 / 3
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"Conditional deletion of Kcnq2 in D1R-MSNs diminished the inhibitory effect of dopamine on KCNQ current and enhanced neuronal excitability and reward behavior ( Figures 6 and 7 )."
36070693
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"Our current results demonstrate that: (1) CCI differentially modulated the firing activity of the VTA-to-NAc and VTA-to-mPFC DA circuits, and of the two, the former is involved in thermal nociception regulation; (2) both KCNQ2 overexpression in the VTA-to-NAc DA neurons and intra-VTA injection of the KCNQ opener retigabine corrected mesolimbic KCNQ channel-mediated M-currents and DA neuronal activity, and relieved CCI-induced thermal nociception; and (3) BDNF signaling in the VTA-to-NAc DA circuit may be involved in the anti-nociceptive effect of retigabine."
33900570
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"Kcnq2 and Kcnq3 have been shown to mediate the release of dopamine after exposure to ethanol."
27063791