IndraLab

Statements

CTNNB1 bound to AXIN inhibits CTNNB1. 3 / 3
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"When Wnt/β-catenin signaling pathway is not activated, the cytoplasmic β-catenin binds to APC, Axin, GSK-3β and CKIε to result in the degradation of β-catenin ( Yau et al., 2005 )."
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"Since GSK3 is a kinase within the beta-catenin destruction complex, which could phosphorylate Axin bound beta-catenin and the phosphorylated beta-catenin is then ubiquitinated and targeted for rapid destruction by the proteasome, preventing activation of beta-catenin target genes XREF_BIBR, XREF_BIBR, GSK3 can act as a negative regulator of beta-catenin."
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"Depletion of another Wnt antagonist, Dapper3, which colocalises with Dishevelled (Dvl) and forms a complex with cytoplasmic proteins Axin, glycogen synthase kinase-3 (GSK3), casein kinase 1 (CK1) and β-catenin causes the accumulation of Dvl2 and β-catenin and aggravates the fibrotic phenotype after UUO [105,106]."
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