IndraLab
Statements
reach
"Depletion of another Wnt antagonist, Dapper3, which colocalises with Dishevelled (Dvl) and forms a complex with cytoplasmic proteins Axin, glycogen synthase kinase-3 (GSK3), casein kinase 1 (CK1) and β-catenin causes the accumulation of Dvl2 and β-catenin and aggravates the fibrotic phenotype after UUO [105,106]."
reach
"Since GSK3 is a kinase within the beta-catenin destruction complex, which could phosphorylate Axin bound beta-catenin and the phosphorylated beta-catenin is then ubiquitinated and targeted for rapid destruction by the proteasome, preventing activation of beta-catenin target genes XREF_BIBR, XREF_BIBR, GSK3 can act as a negative regulator of beta-catenin."