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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

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Statements

Phosphorylated STAT1 increases the amount of USP18. 1 / 1

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"In the absence of USP18, signaling through the JAK-STAT pathway should be enhanced with increased levels of phosphorylated STAT1 and STAT2.We used siRNA to knockdown USP18 expression in MDMs and treated them with IFN-for 18 hours and found increased levels of phosphorylated STAT1 and STAT2 (Fig. 4A )."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...