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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

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INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

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Statements

OTUB1 inhibits proteolysis. 1 / 1

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"We had previously demonstrated that human Otub1 protein leads to degradation of human GRAIL protein, and in a similar manner, murine Otub1 protein leads to murine GRAIL protein degradation (supplemental Fig. 3).4 Ex vivo isolated naive CD4 T cells express no Otub1 protein, thus allowing GRAIL expression (XREF_FIG, first lane), despite the presence of detectable Otub1 mRNA as mTOR mediated protein translation is inactive in these cells."

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INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...