IndraLab

Statements

Modified CBL decreases the amount of EGFR. 4 / 4
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"Increasing evidence suggests that loss of Cbl regulated ErbB1 degradation contributes to ErbB1 overexpression in cancer cells."
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"Western blotting with an antibody that detected EGFR phosphorylated on tyrosine 1068 did show that loss of c-Cbl very moderately increased the overall levels of active EGFR before and after EGF stimulation (XREF_FIG)."
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"136 This finding has therapeutic implications as ectopic c-Cbl expression in osteosarcoma cells could reduce the expression of EGFR and PDGFR-alpha, resulting in decreased cell proliferation and survival, and reduced incidence of lung metastasis in mice."
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"Therapeutically, ectopic c-Cbl expression in osteosarcoma cells could reduce the expression of EGFR and PDGFR-alpha, resulting in decreased cell proliferation and survival and reduced lung metastasis [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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