IndraLab

Statements

MTOR phosphorylates EIF4EBP1 on S6. 6 / 6
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"MTOR complex 1 (mTORC1), regulated by TSC2, phosphorylates ribosomal S6 kinase 1 (S6K1) and eukaryotic initiation factor 4E binding protein 1 (4E-BP1)."
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"The mechanistic target of rapamycin complex 1 (mTORC1) signaling pathway has emerged as a key pathway to trigger cell proliferation and growth through phosphorylating 4E-BP1 and S6 kinase 1 (S6K1) [9]."
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"MTOR complex 1 (mTORC1) phosphorylates S6 kinase 1 (S6K1, a.k.a p70S6) and 4E-BP1 to stimulate protein synthesis (Fig. 2, left hand side), whereas mTOR complex 2 (mTORC2) phosphorylates AKT to promote cell survival (129)."
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"Activated mTOR regulates mRNA translation, ribosomal biosynthesis, protein translation initiation, and other important physiological functions in podocytes in diabetic individuals by phosphorylating the ribosomal S6 kinase 1 (40S ribosomal 6 kinase 1, S6K1) and the eukaryotic initiation factor 4E binding protein 1 (4EBP1) [12,13], which reduce autophagy."
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"Our results showed that the protein expression of p-mTOR, mTOR-mediated phosphorylation of 4E-binding protein 4 (4E-BP1), p70 ribosomal S6 protein kinase 1 (S6K1) as well as phosphatidylinositide 3-kinase (p-PI3K) pathways were amplified in the superficial dorsal horn of the spinal cord of bone cancer rats compared with control rats."
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"MTOR activation results in phosphorylation of S6 kinase and 4E-BP1 (145) with both proteins showing increased phosphorylation in SLE (84)."
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