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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

USP14 activates USP14. 2 / 4

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"H/R treatment substantially enhanced the expression levels of USP14 mRNA and protein expression (Figure 3A–C), and p‐p65 protein expression (Figures 3B and 3D) in HTR8/Svneo and B6Tert‐1 cell lines.3.4 Depletion of USP14 abrogated H/R-induced upregulation of USP14, p-p65, and proinflammatory cytokines."

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"Furthermore, we found that NCOA4 was upregulated by ubiquitin specific peptidase 14 (USP14) via a deubiquitination process in damaged neurons, and we found evidence of pharmacological inhibition of USP14 effectively reducing NCOA4 levels to protect neurons from ferritinophagy-mediated ferroptosis."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...