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USP14 activates USP14. 4 / 6
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"These results suggested that USP14 expression was upregulated in obese ATMs.To further determine the contribution of USP14 to adipose metabolism and inflammation, we administered an AAV (pAd-USP14 or [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Immunofluorescence showed that GFP (green) was expressed in carotid, and the expression of USP14 was attenuated in AAV-USP14 shRNA compared to the control group, suggesting successful USP14 deletion in mice (Fig. 7A)."
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"H/R treatment substantially enhanced the expression levels of USP14 mRNA and protein expression (Figure 3A–C), and p‐p65 protein expression (Figures 3B and 3D) in HTR8/Svneo and B6Tert‐1 cell lines.3.4 Depletion of USP14 abrogated H/R-induced upregulation of USP14, p-p65, and proinflammatory cytokines."
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"A study has revealed that USP14 can also be activated by AKT-induced phosphorylation or simulated phosphorylation of USP14 at Ser432 and may open the pathway between USP14 and the substrate to release self-inhibition via conformational changes [43]."
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