IndraLab

Statements

CYLD inhibits HDAC6. 13 / 14
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"CYLD mediated HDAC6 inhibition was observed to enhance its association with the MTs, reduce the rate of cytokinesis, and delay cell cycle (XREF_FIG)."
21076528
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"CYLD also inhibits HDAC6, leading to increased acetylated tubulin and less cellular motility, as we saw before [XREF_BIBR]."
23644884
sparser
"CYLD interacts with p62 directly and CYLD can directly inactivate HDAC6, thereby controlling autophagy [ xref ]."
25342597
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"In addition, CYLD inactivates HDAC6, which modulates cilia length [XREF_BIBR]."
28900014
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"We further found by immunofluorescence microscopy a colocalization of CYLD and HDAC6 at the centrosome and basal body and, interestingly, loss of Cyld promoted the localization of HDAC6 at the centrosome and basal body."
27028867
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"CYLD negatively regulates cell-cycle progression by inactivating HDAC6 and increasing the levels of acetylated tubulin."
19893491
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"Taken together, these findings suggest that CYLD, TSA, and tubacin act within the same pathway to inhibit HDAC6, which results in elevated levels of acetylated alpha-tubulin."
19893491
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"CYLD inhibits HDAC6 activity by binding to its catalytic domains."
19893491
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"CYLD negatively regulates the cell cycle by inactivating HDAC6, a histone deactylase, and increases the concentration of acetylated tubulin."
26370355
sparser
"CYLD also inhibits HDAC6, leading to increased acetylated tubulin and less cellular motility, as we saw before [ xref ]."
23644884
sparser
"Moreover, CYLD is also able to inhibit HDAC6, a member of the HDAC family whose major substrate is α-tubulin, has become a target for drug development to treat cancer due to its major contribution in oncogenic cell transformation xref ."
22911729
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"Moreover, CYLD is also able to inhibit HDAC6, a member of the HDAC family whose major substrate is alpha-tubulin, has become a target for drug development to treat cancer due to its major contribution in oncogenic cell transformation XREF_BIBR."
22911729
sparser
"In addition, CYLD inactivates HDAC6, which modulates cilia length [ xref ]."
28900014