The INDRA Database

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"CYLD interacts with p62 directly and CYLD can directly inactivate HDAC6, thereby controlling autophagy [ xref ]."

25342597

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"We further found by immunofluorescence microscopy a colocalization of CYLD and HDAC6 at the centrosome and basal body and, interestingly, loss of Cyld promoted the localization of HDAC6 at the centrosome and basal body."

27028867

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"CYLD negatively regulates the cell cycle by inactivating HDAC6, a histone deactylase, and increases the concentration of acetylated tubulin."

26370355

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"In addition, CYLD inactivates HDAC6, which modulates cilia length [XREF_BIBR]."

28900014

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"CYLD also binds and inactivates the histone deacetylase 6 (HDAC6), therefore driving tubulin acetylation and primary cilia formation ( Yang et al., 2014 )."

31067453

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"CYLD also inhibits HDAC6, leading to increased acetylated tubulin and less cellular motility, as we saw before [XREF_BIBR]."

23644884

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"In the normal conditions, CYLD inactivates HDAC6 to promote primary ciliary homeostasis as well as inhibit EMT program; however, during pulmonary fibrosis, CYLD deficiency relieves its inhibitory interaction with HDAC6, thereby leading to primary disassembly and the EMT program (Fig. 6L)."

39122680

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"Studies have identified that CYLD is able to inhibit the function of class II histone deacetylases HDAC6 and HDAC7 by interacting with their catalytic domain [26–28]."

38287022

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"Taken together, these findings suggest that CYLD, TSA, and tubacin act within the same pathway to inhibit HDAC6, which results in elevated levels of acetylated alpha-tubulin."

19893491

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"Moreover, CYLD is also able to inhibit HDAC6, a member of the HDAC family whose major substrate is alpha-tubulin, has become a target for drug development to treat cancer due to its major contribution in oncogenic cell transformation XREF_BIBR."

22911729

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"CYLD mediated HDAC6 inhibition was observed to enhance its association with the MTs, reduce the rate of cytokinesis, and delay cell cycle (XREF_FIG)."

21076528

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"Moreover, CYLD is also able to inhibit HDAC6, a member of the HDAC family whose major substrate is α-tubulin, has become a target for drug development to treat cancer due to its major contribution in oncogenic cell transformation xref ."

22911729

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"HDAC6 interacts with and is inhibited by the deubiquitinating enzyme cylindromatosis (CYLD) at the perinuclear region, significantly delaying the G1-to-S-phase transition, and in the midbody where it [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

29133216

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"In addition, CYLD inactivates HDAC6, which modulates cilia length [ xref ]."

28900014

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"CYLD inhibits HDAC6 activity by binding to its catalytic domains."

19893491

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"CYLD also inhibits HDAC6, leading to increased acetylated tubulin and less cellular motility, as we saw before [ xref ]."