IndraLab

Statements

PSMD14 activates TP53BP1. 4 / 4
| 4
reach
"POH1 is recruited to the IRIF core in a BRCA1 dependent manner, and promotes the clearance of RAP80, the ubiquitin chain and 53BP1 from the IRIF core in G2 phase cells in the late stages of DDR [XREF_BIBR]."
26983989
reach
"Co-depletion of POH1 and RAP80, BRCC36 or ABRAXAS allows establishment of the 53BP1 and ubiquitin chain-devoid core."
24013561
reach
"Of note, we have previously observed that the enlargement and creation of a devoid core represent distinct steps since siRNA POH1 (a component of the proteasome) allows expansion of 53BP1 but the devoid core does not form."
26206670
reach
"XREF_BIBR Importantly co-depletion of POH1 and BRCC36 did not elicit 53BP1 foci larger than POH1 depletion alone, suggesting these DUBs act in the same mechanistic pathway to restrict 53BP1 assemblies."
23075493