IndraLab

Statements

PSMD14 activates TP53BP1. 4 / 4
| 4
reach
"XREF_BIBR Importantly co-depletion of POH1 and BRCC36 did not elicit 53BP1 foci larger than POH1 depletion alone, suggesting these DUBs act in the same mechanistic pathway to restrict 53BP1 assemblies."
23075493
reach
"POH1 is recruited to the IRIF core in a BRCA1 dependent manner, and promotes the clearance of RAP80, the ubiquitin chain and 53BP1 from the IRIF core in G2 phase cells in the late stages of DDR [XREF_BIBR]."
26983989
reach
"Co-depletion of POH1 and RAP80, BRCC36 or ABRAXAS allows establishment of the 53BP1 and ubiquitin chain-devoid core."
24013561
reach
"Of note, we have previously observed that the enlargement and creation of a devoid core represent distinct steps since siRNA POH1 (a component of the proteasome) allows expansion of 53BP1 but the devoid core does not form."
26206670