IndraLab

Statements

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"The research of Peth et al. [ xref ] reveals that Uch37 can also activate ATPase subunits and promote 20S CP to open the degradation channel, which indicates that it can affect the conformation of proteasome just like Ubp6."
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"When loaded with a ubiquitinated substrate, UCHL5 also activates ATPase activity and 20S gate opening of the proteasome purified from USP14 knockout mammalian cells [ xref ], suggesting UCHL5 may function as another check point to coordinate substrate entry and processing."
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"On the other hand, binding of polyubiquitinated proteins to USP-14 and UCHL5 can also activate proteasomal ATPases ( Peth et al., 2013 )."
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