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CK2 phosphorylates NPM1. 18 / 18
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"Phosphorylation of Npm is catalyzed by CK2 and the cyclin dependent kinase cdc2 and cdk1."
25772360
rlimsp
"These studies suggest that unlike many molecular chaperones, which directly hydrolyze ATP, substrate release by protein B23 is dependent on its phosphorylation by CK2."
12511551
sparser
"Previous reports suggest that CKII kinase phosphorylates S125-NPM ( xref ; xref )."
24290756
sparser
"CKII phosphorylates NPM1 during interphase and regulates its nucleolar retention and ribosome biogenesis function, whereas the activity and expression of Aurora kinases A and B peak during the G2/M ph[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
24857377
rlimsp
"The presence of bound substrate enhanced the rate of CK2 phosphorylation of protein B23 by 2-3-fold, and this enhancement was dependent on a nonpolar region in its N-terminal end."
12511551
rlimsp
"Furthermore, CK2 phosphorylation of a previously formed B23-substrate complex promoted its dissociation."
12511551
reach
"As shown in Fig. 7, nucleophosmin and B23 was phosphorylated by CK2 associated with the cyclin H, cdk7, and Mat1 complex and this phosphorylation was completely inhibited by the CK2 specific substrate[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12147220
reach
"Several laboratories have reported on CK2 phosphorylation of B23/nucleophosmin, including androgenic regulation, cell cycle regulation, and the impact on genes related to protein synthesis, energetic metabolism, and ribosomal biogenesis [122–126]."
36114992
sparser
"In publications outside of digestive cancers, NPM1 is also phosphorylated by casein kinase 2, polo-like kinase 2, CDC2, and cyclin E/CDK2 complex [ xref ]."
36428674
sparser
"Recent studies show that NPM phosphorylation by CKII is involved in ribosome biogenesis by increasing its binding affinity to other nucleolar components as well as positively regulating nuclear import[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
17113241
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"Since CK2 has been shown to be another major kinase that phosphorylates NPM on the residues other than Thr 199 [21] , in vitro kinase reaction was also performed with CK2 as a control."
16376875
reach
"Phosphorylation of GST-NPM/wt (lane 5) and GST-NPM/T199A (lane 6) by CK2 was not detected by this antibody."
16376875
rlimsp
"Phosphorylation of protein B23.1 by casein kinase II produced an additional doubling of the import rate."
9092824
reach
"Interestingly, CIGB-300 was shown to bind NPM1 and to inhibit CK2-mediated phosphorylation of NPM1 at Ser125 inducing damage to the nucleolar architecture and massive apoptosis [149], in line with the putative implication of NPM1 phospho-Ser125 in the maintenance of the nucleolar assembly, in ribosome biogenesis, and in cytokinesis [153,154,155]."
32664415
sparser
"Thus, these results suggest that NPM phosphorylation by CKII is necessary step for ribosome biogenesis."
17113241
rlimsp
"Phosphorylation of protein B23 by casein kinase II enhanced its affinity for the SV40 T- and Rev-derived peptides approximately 2-fold."
7794916
reach
"The study demonstrated that CIGB-300 inhibited CK2-dependent phosphorylation of NPM1 at S125 and induced nucleolar disorganization."
36877156
reach
"In publications outside of digestive cancers, NPM1 is also phosphorylated by casein kinase 2, polo-like kinase 2, CDC2, and cyclin E/CDK2 complex [117]."
36428674