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CK2 phosphorylates NPM1. 13 / 18
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"Phosphorylation of Npm is catalyzed by CK2 and the cyclin dependent kinase cdc2 and cdk1."
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"Previous reports suggest that CKII kinase phosphorylates S125-NPM ( xref ; xref )."
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"CKII phosphorylates NPM1 during interphase and regulates its nucleolar retention and ribosome biogenesis function, whereas the activity and expression of Aurora kinases A and B peak during the G2/M ph[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"As shown in Fig. 7, nucleophosmin and B23 was phosphorylated by CK2 associated with the cyclin H, cdk7, and Mat1 complex and this phosphorylation was completely inhibited by the CK2 specific substrate[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Several laboratories have reported on CK2 phosphorylation of B23/nucleophosmin, including androgenic regulation, cell cycle regulation, and the impact on genes related to protein synthesis, energetic metabolism, and ribosomal biogenesis [122–126]."
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"In publications outside of digestive cancers, NPM1 is also phosphorylated by casein kinase 2, polo-like kinase 2, CDC2, and cyclin E/CDK2 complex [ xref ]."
36428674
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"Recent studies show that NPM phosphorylation by CKII is involved in ribosome biogenesis by increasing its binding affinity to other nucleolar components as well as positively regulating nuclear import[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Since CK2 has been shown to be another major kinase that phosphorylates NPM on the residues other than Thr 199 [21] , in vitro kinase reaction was also performed with CK2 as a control."
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"Phosphorylation of GST-NPM/wt (lane 5) and GST-NPM/T199A (lane 6) by CK2 was not detected by this antibody."
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"Interestingly, CIGB-300 was shown to bind NPM1 and to inhibit CK2-mediated phosphorylation of NPM1 at Ser125 inducing damage to the nucleolar architecture and massive apoptosis [149], in line with the putative implication of NPM1 phospho-Ser125 in the maintenance of the nucleolar assembly, in ribosome biogenesis, and in cytokinesis [153,154,155]."
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"Thus, these results suggest that NPM phosphorylation by CKII is necessary step for ribosome biogenesis."
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"The study demonstrated that CIGB-300 inhibited CK2-dependent phosphorylation of NPM1 at S125 and induced nucleolar disorganization."
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"In publications outside of digestive cancers, NPM1 is also phosphorylated by casein kinase 2, polo-like kinase 2, CDC2, and cyclin E/CDK2 complex [117]."
36428674