IndraLab

Statements

TNF activates CYLD. 25 / 28
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"TNF-alpha treatment failed to activate the cyclin D1 promoter in Cyld +/+ as well as Cyld -/- keratinocytes, consistent with the inability of TNF-alpha to stimulate keratinocyte proliferation."
16713561
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"Furthermore, the CYLD overexpressed H460 cells were treated with 100ng/mL of TNF-alpha in combination with different concentrations of Nec-1 for 24 hours, including 0muM, 0.1 muM, 1.0 muM, and 10muM, respectively (XREF_FIG)."
27738385
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"Immunoprecipitation of FADD from CYLD expressing and control Cyld -/- MEFs treated with TNF in the presence of zVAD-fmk revealed that recruitment of RIPK1 to the FADD necrosome is strictly dependent on CYLD (XREF_FIG)."
22037414
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"In addition, TRAF2 and TRAF6 appear to be differentially involved in NF-kappaB-dependent induction of CYLD by TNF-alpha and NTHi."
15226292
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"In detail, both SPATA2 and CYLD were induced by TNF-alpha and IL-1beta (but not FSH) after 3hours."
30697874
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"A20, Cezanne, and CYLD were all activated by TNF-alpha."
25907801
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"To test this hypothesis, Cyld -/- MEFs stably reconstituted with CYLD-WT or CYLD-D215A were treated with TNF."
22037414
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"In contrast, MEFs expressing CYLD-WT only underwent significant amounts of necrosis if treated with TNF in the presence of IETD-fmk (XREF_FIG) or zVAD-fmk (XREF_FIG)."
22037414
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"After 48 h of infection, these cells were transfected with CYLD along with NF-kappaB luciferase reporter and treated with TNFalpha for 4 h after 22 h of transfection."
21408173
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"CYLD mRNA is upregulated by TNF alpha and bacterium nontypeable Haemophilus influenza, providing evidence for an inducible autoregulatory feedback loop controlling CYLD expression (Jono et al., 2004)."
17851586
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"Furthermore, NF-kappaB-dependent induction of CYLD by TNF-alpha triggers an autoregulatory feedback mechanism through deubiquitylation of TRAF2 and TRAF6 [37]."
20347313
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"After 48 h of infection, cells were transfected with CYLD expression plasmid or left untransfected and treated with TNFalpha for 10 min after 30 h of transfection."
21408173
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"However, although A20 and CYLD are induced by TNFalpha for the establishment of a negative feedback loop, neither OTULIN (XREF_FIG F) nor LUBAC are induced by TNFalpha, again suggesting that they function as a differentially regulated signaling module."
23746843
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"Recently, Reiley and colleagues have generated Cyld −/− mice, and found that there was no significant difference in TNFα-induced NF-κB signaling in Cyld −/− vs wildtype bone marrow–derived macrophages[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
18068998
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"In agreement with our results, Jono et al. have demonstrated an autoregulatory feedback mechanism through which activation of NF-kappaB by TNFalpha induces CYLD that in turn leads to the negative regu[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
19800320
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"Knockdown of CYLD had no effect on cell death of NEMO deficient cells treated with TNF in the absence of zVAD, i.e. CYLD is not required when the cell death is apoptotic (XREF_FIG)."
22848449
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"Interestingly, the tumor suppressor CYLD, which is induced by TNFalpha and negatively regulates NF-kappaB signaling and adlican, which is involved in colon cancer progression, were both up-regulated in cartilage from patients with late-stage OA."
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"On the other hand, CYLD also acts as a mediator of immune activation and inflammation.38, 39 We found that both SPATA2 and CYLD are induced by TNF-alpha and IL-1beta in vitro, indicating a similar regulation in OC."
30697874
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"TLR4-TRIF signaling and not TNF mediates CASPASE-8 dependent cleavage of CYLD."
27264187
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"The cleavage of CYLD induced by TNFα is mediated by caspase-8 (O'Donnell et al. 2011)."
28701375
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"The CYLD cleavage induced by TNFα could be inhibited by both Nec-1s and zVAD.fmk or the RIPK1 D138N knock-in kinase-dead mutation (Polykratis et al. 2014), indicating a role of RIPK1 kinase activity in the activation of caspase-8 (Fig. 2F; Supplemental Fig. S5B)."
28701375
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"The stable cell line of CYLD overexpressing A549 cells was treated with 10ng/mL of TNF-alpha alone, or 20ng/mL of TNF-alpha combinated with 10muM of a pancaspase inhibitor, z-VAD-fmk, for 12 hours, and the cell apoptosis rate and necrosis rate were determined by Annexin v-FITC/PI dual staining analysis following the kit protocols (Santa Cruz, USA)."
27738385
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"Moreover, CYLD overexpressed H460 cells were treated with 100ng/mL of TNF-alpha in combination with or without 10muM of z-VAD-fmk for 24 hours."
27738385
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"In the other treatment, the stable cell line H460 cells with overexpression of CYLD-flag or negative control plasmid were treated with TNF-alpha at the increasing concentration of 0ng/mL, 1ng/mL, 20ng/mL, and 400ng/mL for 20 hours."
27738385
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"Hence, up-regulation of CYLD by TNFalpha can occur independent of PrP."
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