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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

SCF Fbxo22 methylates TP53. 2 / 2

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"Taken together, the results strongly suggest that SCF Fbxo22 preferentially targeted methylated p53, but not acetylated p53, in ubiquitin dependent degradation."

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"Given that previous mass spectrometry revealed that Fbox22 formed a stable complex with KDM4A XREF_BIBR and that SCF Fbxo22 preferentially targeted methylated p53, we speculated that SCF Fbxo22 might form a ternary complex with p53 and KDM4A."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...