IndraLab

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TRAF6 binds USP4. 17 / 19
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"As previously reported, TRAF6 is a key adaptor molecule for the activation of the NF-kappaB pathway 31, therefore it was speculated that USP4 indeed interacts with TRAF6."
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"The USP domain is responsible for USP4 to interact with TRAF6."
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No evidence text available
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"We found that USP4 specifically interacts with TRAF2 and TRAF6, but not TRAF3."
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"Xiao et al. 's study added on to this by demonstrating USP4 's interaction and deubiquitination of TRAF2 and TRAF6, but not TRAF3, both in vivo, in HEK293T cells, and in vitro [XREF_BIBR]."
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"Moreover, USP4 associates with TRAF6 both in vitro and in vivo, independent of its deubiquitinase activity."
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No evidence text available
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"As shown in Fig.  xref , the interaction between USP4 and TRAF6 was not impaired by the mutation of the Cys-311 to Alanine (‘CA mutant’) of USP4 molecule."
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No evidence text available
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"Flag-TRAF6 and HA-USP4 plasmids were co-transfected into HEK293T cells and after 48h, further IP experiments were performed with anti-HA antibody, and it was established that USP4 interacted with TRAF6."
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"Xiao et al.'s study added on to this by demonstrating USP4's interaction and deubiquitination of TRAF2 and TRAF6, but not TRAF3, both in vivo, in HEK293 T cells, and in vitro [61] ."
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"To further map the functional domain that interacts with TRAF6, we generated two truncated constructs based on the structural domains of USP4 and as shown in Fig.  xref , only the C-terminal domain (C) of USP4 was able to interact with TRAF6."
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"XREF_FIG, the interaction between USP4 and TRAF6 was not impaired by the mutation of the Cys 311 to Alanine (' CA mutant ') of USP4 molecule."
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"USP4 interacts with and deubiquitinates TRAF6, thereby preventing the activation of NF-kappaB and AP-1 transcription factors and subsequent immune responses."
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"As previously reported, TRAF6 is a key adaptor molecule for the activation of the NF-κB pathway xref , therefore it was speculated that USP4 indeed interacts with TRAF6."
30194441
biogrid
No evidence text available
22029577
sparser
"Flag-TRAF6 and HA-USP4 plasmids were co-transfected into HEK293T cells and after 48 h, further IP experiments were performed with anti-HA antibody, and it was established that USP4 interacted with TRAF6 (Fig.  xref )."
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