IndraLab

Statements

Metformin inhibits NLRP3. 49 / 49
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"Combined Administration of Metformin and Atorvastatin Inhibited NLRP3 Inflammasome in H9C2 Cells Exposed to Palmitate via Toll Like Receptor 4/NF-kappaB Signaling Pathway."
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"Metformin and resveratrol could suppress dynamin‐related protein 1 activity and prevent activation of the NLRP3 inflammasome by limiting ER stress to reverse the damage process and protect mitochondrial integrity."
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"Metformin, the most widely used drug for treating T2D, can inhibit NLRP3 by activating AMPK (AMP activated protein kinase), thus increasing autophagy activity to promote the clearance of inflammasomes via inhibiting the mTOR pathway and alleviating the symptoms in diabetic cardiomyopathy."
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"Metformin reduced NLRP3 inflammasome activity in Ox-LDL stimulated macrophages through adenosine monophosphate activated protein kinase and protein phosphatase 2A."
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"We provide evidence that metformin inhibits the NLRP3 inflammasome priming and activation in microglia."
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"Furthermore, metformin activated phosphorylated AMPK, decreased pro inflammatory cytokines, TNF-alpha, IL-6 and IL-1beta, and decreased NLRP3 inflammasome activation."
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"Metformin inhibits NLRP3 inflammasome activation."
| PMC
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"In order to indicate whether metformin and atorvastatin could inhibit NLRP3 inflammasome activation, the expression levels of NLRP3 and its downstream molecules (caspase-1 and IL-1beta) were detected by Western blot assay."
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"In addition, Yang et al. verified that metformin could inhibit the NLRP3 inflammasome by activating the AMPK and mTOR pathway in diabetic cardiomyopathy."
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"PGC-1alpha induction with the plasmid and metformin improved mitochondrial dynamics and morphology and attenuated the NLRP3 inflammasome and cell injury."
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"We show that metformin inhibited NLRP3 inflammasome activation and interleukin (IL)-1beta production in cultured and alveolar macrophages along with inflammasome independent IL-6 secretion, thus attenuating lipopolysaccharide (LPS) - and SARS-CoV-2-induced ARDS."
| PMC
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"Combined Treatment With Metformin and Atorvastatin Inhibited Activation of NLRP3 Inflammasome in Heart Tissues of db/db Mice."
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"In addition, Guo et al [XREF_BIBR] found that the pioglitazone metformin complex preparation could reduce inflammation, inhibit activation of the NLRP3 inflammasome, and reduce the release of IL-1beta in the treatment of PCOS."
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"Sustained metformin administration reduces macrophage NLRP3 inflammasome activation in diabetic individuals and in non myeloid cells via an AMP activated protein kinase (AMPK)-dependent and poorly defined mechanism."
| PMC
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"Interestingly, even glucose in high concentrations activates NLRP3 inflammasome in trophoblasts, and a recent study showed that metformin inhibits NLRP3 through the AMPK/mTOR pathway."
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"Furthermore, after stimulation with the mTOR inhibitor rapamycin, additional metformin treatment could still downregulate Nek7 and NLRP3."
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"Besides, Metformin inhibits NLRP3 activation through the AMPK/mTOR signaling pathway and promotes M2-type polarization of Mp, and is beneficial to Non-DW healing (Qing et al., 2019)."
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"Metformin also inhibits ROS accumulation and NLRP3 inflammasome activation stimulated by high glucose in macrophages which is blocked by compound C."
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"Metformin also inhibited the interaction of TXNIP and NLRP3 [XREF_BIBR]."
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"We show that metformin inhibited NLRP3 inflammasome activation and interleukin (IL)-1beta production in cultured and alveolar macrophages along with inflammasome independent IL-6 secretion, thus attenuating lipopolysaccharide (LPS) - and SARS-CoV-2-induced ARDS."
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"Among the last ones, a remarkable effect of metformin in preventing LPS-induced IL-1β mRNA levels was found, thus further supporting our in vitro study showing that metformin highly inhibits NLRP3 inflammasome priming in microglia.Under brain pathological conditions, microglial checkpoints pathways sense the environment to prevent overreaction to external stimuli."
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"In our study, we observed that Metformin significantly suppressed accumulation of the NLRP3 inflammasome and activation of Caspase-1."
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"Overall, metformin inhibited the activation of NLRP3 inflammasome, decreased cartilage degradation, reversed subchondral bone remodelling and inhibited chondrocyte pyroptosis."
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"Metformin reduced the activity of NLRP3 in primary urothelial cells."
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"A number of scholars pointed out that metformin could inhibit NLRP3 inflammasome by activating the AMPK and mTOR signaling pathway."
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"In addition, metformin, a drug widely used for diabetes, was reported to indirectly inhibit the NLRP3 inflammasome via the regulation of the mechanistic target of rapamycin mechanistic target of rapamycin kinase (mTOR) protein, which is related to the reduction in the mortality of COVID-19 and type 2 diabetes mellitus (T2DM) patients [149]."
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"Metformin Inhibits the NLRP3 Inflammasome via AMPK and mTOR dependent Effects in Diabetic Cardiomyopathy."
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"Metformin reduces the activity of NLRP3 inflammasomes by inhibiting the expression of Nek7, and significantly reduces experimental diabetic periodontitis in vivo and in vitro (Zhou et al., 2019)."
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"Metformin was also recently shown to inhibit NLRP3 activation and lung inflammation in SARS-CoV-2-infected mice ."
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"The aim of this study was to investigate whether metformin can inhibit the NLRP3 inflammasome by activating the AMPK and mTOR pathway in DCM."
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"These results further confirm that inhibition of mtROS production is not required for metformin inhibition of NLRP3 inflammasome activation."
| PMC
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"Furthermore, after stimulation with the mTOR inhibitor rapamycin, additional metformin treatment could still downregulate Nek7 and NLRP3."
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"Metformin inhibited NLRP3 inflammasomes activation and suppressed diabetes accelerated atherosclerosis in apoE -/- mice, which at least partially through activation of AMPK and regulation of thioredoxin-1 and thioredoxin-interacting protein."
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"We further found that metformin significantly suppressed NLRP3 inflammasome activation, subsequent caspase-1 cleavage, and interleukin-1beta secretion in both peripheral macrophages and central hippocampus."
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"In SARS-CoV-2-infected mice, metformin has also been shown to inhibit the activation of the NLRP3 inflammasome and its-mediated lung inflammation [149]."
35944881
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"Metformin Inhibits NLR Family Pyrin Domain Containing 3 ( NLRP ) - Relevant Neuroinflammation via an Adenosine-5 ' - Monophosphate-Activated Protein Kinase ( AMPK ) - Dependent Pathway to Alleviate Early Brain Injury After Subarachnoid Hemorrhage in Mice ."
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"Although metformin attenuated mtROS accumulation in macrophages treated with the NLRP3 activators ATP and nigericin, this effect was not important for inhibition of NLRP3 inflammasome activation which was not reversed by treatment of metformin incubated macrophages with the mtROS generators mitoParaquat and DMNQ."
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"[55] Besides, metformin a first-line drug in the management of T2DM, acts through activation of AMP-activated protein kinase (AMPK) and blocking of mitochondrial complex I. [56] Metformin inhibits NLRP3 inflammasome through AMPK activation and autophagy with mTOR pathway inhibition in dilated cardiomyopathy."
| DOI
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"It has been shown that metformin is able to decrease the activation of NLRP3 in various tissues (Lee et al., 2013; Bullón et al., 2016; Li et al., 2016)."
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"Metformin can inhibit the NLRP3 inflammasome activation in apolipoprotein E (apoE) -/- mice and inhibit diabetes accelerated AS, at least in part by activating AMPK and regulating thioredoxin-1 and thioredoxin interacting protein."
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"The diabetes drug metformin indirectly inhibits NLRP3 by regulating mTOR, and its use is significantly associated with reduced mortality among patients with COVID-19 and type 2 diabetes."
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"These results show that metformin reduces NLRP3 protein expression and activation via AMPK and PP2A in oxLDL-induced macrophages ( 71 ) ."
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"To determine whether short-term metformin treatment inhibits NLRP3 dependent inflammation invivo we used the alum induced peritonitis model."
| PMC
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"Metformin and resveratrol protected mitochondrial integrity by inhibiting Drp1 activity and prevented NLRP3 inflammasome activation by suppressing ER stress, and thereby protected adipose function from high glucose insult."
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"71 Metformin and empagliflozin, two well-known antidiabetic drugs, inhibited NLRP3 inflammasome and decelerated the development of diabetic cardiomyopathy but via different mechanisms."
| PMC
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"Metformin stimulates mitophagy by activating AMPK, and mitophagy limits NLRP3 inflammasome activation."
| PMC
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"Additionally, compared with the control group, metformin supply reduced the activation of NLRP3 (P < 0.05)."
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"[55] Besides, metformin a first-line drug in the management of T2DM, acts through activation of AMP-activated protein kinase (AMPK) and blocking of mitochondrial complex I. [56] Metformin inhibits NLRP3 inflammasome through AMPK activation and autophagy with mTOR pathway inhibition in dilated cardiomyopathy."
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"These results indicate that metformin can inhibit NLRP3 inflammasome activation in apoE -/- mice and inhibit diabetes accelerated AS, at least in part by activating AMPK and regulating thioredoxin-1 and thioredoxin interaction protein."
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