IndraLab

Statements

reach
"BK channel activation with NS-1619 (30 muM) significantly inhibited the amplitude, muscle force, frequency, duration, and tone of the spontaneous phasic and pharmacologically induced DSM contractions from human DSM isolated strips."
22422396
reach
"The inhibitory effect of selective BK channel activation with NS1619 on electrical field stimulation-induced contractions is attenuated in DSM strips isolated from HFD rats."
31480021
reach
"XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR On the other hand, well established (such as NS1608, NS8 and NS1619) and novel (such as NS11021) BK channel openers increase BK channel open probability and whole-cell BK currents, causing DSM hyperpolarization and relaxation in various species."
22158596
reach
"27 The Petkov research group proposes the novel hypothesis that BK channels are key determinants of age- and sex related differences in bladder physiology, and therefore changes in BK channel expression, function, or regulation may underlie age and sex specific DSM dysfunction and resultant LUTD."
26872571
reach
"By reducing overall DSM excitability, BK channel activation with NS1619 can significantly diminish spontaneous, pharmacologically induced and nerve evoked contractions."
21914438
reach
"BK channel inhibition with paxilline (1 muM) attenuated the PGE 2 -induced DSM phasic contractions, suggesting that BK channels are involved in the mechanism of PGE 2 -induced DSM contractions."
24886877
reach
"BK channel pharmacological inhibition with IBTX completely blocked the NS1619 induced relaxation of rat DSM confirming NS1619 selectivity for the BK channel."
21914438
reach
"Here, we examined systematically how the BK channel pharmacological activation modulates DSM contractility."
21914438