IndraLab

Statements

JAK2 phosphorylates JAK2. 110 / 118
3 | 91 19 3
reach
"Leptin-mediated signaling begins by the binding of leptin to the leptin receptor (ObR), phosphorylation of Janus kinase 2 (JAK2), and then subsequent cascade signaling involving the activation of STAT3, mitogen-activated protein kinases (MAPK), and PI3-kinases/Akt [64] (Figure 2)."
37511077
reach
"Tyrophostin B42, a specific inhibitor of JAK-2 [30], inhibits the phosphorylation of JAK-2, the activation of STAT1alpha, and the induction of iNOS [29], suggesting that the JAK-2-STAT1alpha pathway i[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
15683721
reach
"The JAK2/STAT signalling pathway is activated via phosphorylation and activation of JAK2 followed by recruitment and phosphorylation of STATs."
35033662
reach
"Moreover, we also certified that IL-6 could activate JAK2 and STAT3 pathways in OSCC cells.It is reported that JAK2/STAT3 can receive extracellular stimulation signals through inflammatory cytokine receptors, then induce JAK2 and STAT3 phosphorylation and regulate the expression of downstream genes [30, 31]."
35513871
reach
"RORγt rabbit polyclonal antibody, phosphorylation of Janus kinase 2 (p-JAK2) rabbit polyclonal antibody, phosphorylation of signal transducers and activators of transcription 3 (p- STAT 3) rabbit poly[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
37268260
sparser
"EPO binds to two cell surface Epo receptors (EPORs), which form disulfide‐linked homodimers, and selectively activates JAK2 kinase, which in turn phosphorylates Jak2 and EPOR."
32506750
reach
"First, we have shown that Jak2-specific inhibitor, AG490, strongly suppressed Jak2 phosphorylation and iNOS expression in LPS-treated cells ( Fig. 5 )."
16139249
reach
"Upon leptin binding to LepRb, JAK2 non-covalently associates with the receptor, allowing JAK2 autophosphorylation and subsequent phosphorylation of LepRb at discrete sites, including tyrosines at posi[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
25172030
reach
"The binding of GH to cell surface homodimeric GHR, a type I cytokine receptor lacking intrinsic tyrosine kinase activities, initiates Janus kinase 2 (JAK2)-dependent (8) signal transduction, in which JAK2 phosphorylates the 7 tyrosines within the human GHR intracellular domain (9), and phosphorylates signaling components recruited to the activated GHR (Figure 1)."
33029712
reach
"Because Stat3 activation is primarily mediated by Jak2, XREF_BIBR the levels of Jak2 phosphorylation, Stat3 tyrosine 705 phosphorylation (a primary activating phosphorylation site on Stat3), and the expression levels of Stat3 were assessed in the cells treated with selected strong anti-Stat3 herbal extracts."
28664080
reach
"Treatment with JAK2-specific inhibitor AZD1480 decreased JAK2 phosphorylation and also reduced AMPK phosphorylation (P < 0.05, Figure 8(a))."
32733634
reach
"Overall these results show that extracellular ligands that enforce large receptor dimer separation and different binding geometries can counteract intracellular oncogenic ligand independent receptor activation, presumably by exceeding the accessible distance that the JAK2 kinase domain can extend to transphosphorylate the opposing JAK2 and receptor (XREF_FIG)."
25728669
reach
"Further analysis of the JAK and STAT pathway suggests a model for the IFN-gamma response in which the initial phosphorylation of JAK1 and JAK2 is mediated by JAK2, whereas phosphorylation of the IFN-gamma receptor is normally carried out by JAK1."
8631301
sparser
"The model presented is one in which GH binding to two GHRs causes dimerization of GHR, activation of the GHR-associated JAK2 tyrosine kinase, and tyrosyl phosphorylation of both JAK2 and GHR."
8815791
sparser
"Type I JAK2 inhibitors induce paradoxical JAK2 hyperphosphorylation in these leukemias and have limited activity."
26175414
reach
"Mutant CALR was also found to induce Jak2 phosphorylation and activation of Jak2 downstream signaling, an effect that can be blocked by Jak2 inhibitors."
37760623
reach
"In agreement with previous findings, JAK2 phosphorylation was increased upon B. abortus infection, and the stimulation of PAFR by PAF boosts JAK2 activation (increased values of 14.78% at 5min and 14.49% at 15min) during B. abortus uptake."
27098179
sparser
"Depending on cellular context, V617F JAK-2 can induce a strong phosphorylation of JAK-2 in absence of exogenous stimuli in 293T cells [6] or a subtle effect in presence of low concentrations of cytoki[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
16263414
sparser
"On the contrary, knockdown of RAC3 markedly reduced the protein levels of JAK2 and phosphorylated JAK2 ( xref )."
33062641
reach
"Furthermore, IL-13 induces the phosphorylation of Janus Kinase 2 (JAK2), followed by increased nuclear translocation of phosphorylated signal transducers and activators of transcription 6 (STAT6), leading to downregulated ezrin expression, which is related to IL-13-induced epithelial injury [93]."
36530558
reach
"A ligand-induced receptor homodimer conformational change leads to trans-phosphorylation and activation of Janus kinase 2 (JAK 2 ) ( Socolovsky et al., 1998; Wojchowski et al., 1999 )."
19735711
reach
"Next, JAK2-specific inhibitor AG490 caused significant decreases in the phosphorylation of JAK2 and STAT3 proteins and levels of SOCS3 protein."
32044397
reach
"Preclinical studies show that selective inhibition of JAK2 with fedratinib reduced phosphorylation of JAK2 and other proteins from the STAT family in cHL and PMBCL cell lines."
24952250
reach
"Xie et al. [26, 27] have reported that JAK2 and ABL bonding could elicit JAK2 phosphorylation, which was not affected by BCR-ABL tyrosine kinase inhibitors, such as imatinib."
38716474
reach
"Leptin binding to ObR activates janus tyrosine kinase 2 (JAK2), which promotes JAK2 phosphorylation."
30386207
reach
"As previously shown ( Guo et al., 1998 ), we found that TNFα induced tyrosine phosphorylation of JAK2 and pretreatment with AG490 (a JAK2 tyrosine kinase inhibitor) or kahweol inhibited JAK2 phosphory[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
17097123
reach
"In contrast, JAK2 inhibition not only completely abolished JAK2 and STAT3 phosphorylation (P < 0.05, respectively) (XREF_FIG), but also blocked the increase in Akt phosphorylation level induced by fasudil at both 3 h and 24 h of reperfusion (P < 0.05, respectively)."
23118936
reach
"Also, the binding of leptin to its receptor leads a phosphorylation of Janus kinase 2 (JAK-2) activating the JAK signal transduction [1] ."
25264584
reach
"Taken together, these data suggest that JAK2 can directly phosphorylate CHK2 at Y156.In addition to JAK2, we also tested WEE1, SRC, and EGFR."
35851582
reach
"In line with these findings, we connect JAK2 nuclear translocation to its activity by demonstrating that inhibition of JAK2 induces dephosphorylation of JAK2 at Y1007/1008 and reduces oxidative damage-induced nuclear localization of JAK2."
30548332
reach
"Since nonselective PTK inhibitor (herbimycin A) and Jak-2 kinase inhibitor (AG490) inhibit the IFN-gamma-induced Jak-2 phosphorylation, STAT1alpha binding activity and iNOS expression in DLD-1 cells [[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
11755929
reach
"In the JAK2/STAT5 signaling pathway, activated JAK2 phosphorylates STAT5, which activates the transcription of genes involved in the synthesis of milk proteins, thereby regulating the synthesis of milk proteins [62]."
36768756
reach
"82 The dodecamer formation provides a conformational structure that moves the central intracellular betac domains into close proximity (~ 10 A versus ~ 120 A in the hexamer formation) to enable JAK2 transphosphorylation and initiation of the JAK2 and STAT5 signaling pathway."
28605348
reach
"In the JAK2/STAT3 signaling pathway, 0.1 μg/L quinolone antibiotics and LPS phosphorylated JAK2 protein, and activated JAK2 could phosphorylate STAT3 protein."
35124416
reach
"More importantly, SH2-Bbeta enhanced GH induced tyrosyl phosphorylation of endogenous JAK2 and ligand induced tyrosyl phosphorylation of Stat5B by endogenous JAK2."
10377387
reach
"In an early study, it was shown that following the binding of CCL3 to its CCR5 receptor on T cells, the phosphorylation and activation of Janus kinase 2 (JAK2) was observed, but this was not prevented by inhibition of JAK, indicating that this is only one of many other dependent signals (18)."
39104520
sparser
"Therefore, we examined the protein expression of JAK2 and phosphorylated JAK2, as well as STAT3 and phosphorylated STAT3, in H1975 and H2030 cells."
38387529
reach
"Rabbit polyclonal antibodies RORγt, phosphorylation of Janus kinase 2 (p-JAK2), phosphorylation of signal transducers and activators of transcription 3 (p- STAT 3), and JAK2 were obtained from Affinit[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
38364934
reach
"In white adipose tissue and muscle, retinol-bound RBP4 binding with STRA6 induced the phosphorylation of Janus kinase 2 (JAK2) and increased the expression of signal transducer and activator of the transcription (STAT) target gene Socs3 that potently inhibits insulin signalling."
35448487
reach
"We also found that the JAK2‐specific inhibitor AG490 did not further decrease the ischemia‐induced phosphorylation of JAK2 and STAT3 significantly at 3 and 24 h after reperfusion."
36419252
reach
"Chemical JAK2 inhibition decreased phosphorylation of JAK2, STAT1, STAT3 and STAT6 and reduced the expression of additional downstream targets, including PD-L1, in a copy number dependent manner."
24610827
reach
"It is known that EPO can significantly activate the JAK2-STAT5 signalling by binding to EPOR and then play a role in transcriptional regulation of downstream genes.5 Results showed that the treatment of EPO could increase the expression of NEU3 in RA FLS by promoting the phosphorylation of JAK2 and STAT5, which was inhibited by the EPOR antagonist (EMP9), JAK2 inhibitor (AG490), STAT5 inhibitor (CAS285986) and inhibitor of JAK1 and JAK2 (baricitinib) (figure 6H,I)."
38272667
reach
"The β-galactosidase assay reconstituted in response to Janus kinase 2 (JAK2) phosphorylation induced by EPOR activation (Supplementary Fig. 15a) was used to evaluate EPOR-specific agonist activities of EMP-PA8 and EMP-PA22."
35031676
reach
"JAK2, however, appears to be not able to phosphorylate ABCA1, implying that JAK2 phosphorylates another JAK2-targeted proteins [46,47] ."
21907307
reach
"Upon inhibition of the phosphorylation of JAK2/STAT3 by the JAK2/STAT3 inhibitor AG490, the up-regulated expression and translocation of HMGB1 was reduced and EBI was ameliorated, further highlighting the contribution of JAK2/STAT3 pathway in HMGB1-mediated neuroinflammation in SAH [76]."
32610502
reach
"It was postulated that IL-23 promotes signal transducer and transcriptional activator 3 (STAT3) phosphorylation by Janus kinase 2 (JAK2) and tyrosine kinase 2 (TYK2) by binding to its receptor IL-23R (70, 71)."
34733276
reach
"Although western blot analysis has indicated that PDGF-BB induces the phosphorylation of Src and Janus kinase 2 (JAK2) in pancreatic stellate cells in a time-dependent manner (7), the interaction between Src and PDGF-BB in osteoblast cells is poorly understood.The JAK family consists of four members, JAK1, JAK2, JAK3 and Tyk2, which are activated by cytokines binding their receptor."
30106097
reach
"Results are (mean +/-SEM) of three experiments.Prolactin binding to its receptor results in dimerization of the receptor and the associated Jak2 kinase, allowing trans-phosphorylation and activation o[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
10630404
sparser
"We examined the expression of JAK1, JAK2, and STAT3 and phosphorylated JAK1, JAK2, and STAT3 in RPE cells cocultured with different concentrations of IL-6 for increasing durations with western blotting."
32818015
reach
"Furthermore, an inhibitor of JAK2 and STAT3 pathway, AG490, suppressed IL-1beta-induced intimal proliferation and phosphorylation of JAK2 and STAT3."
26955959
reach
"Moreover, it was also found that JAK2 blocker, AG-490 inhibited JAK2 phosphorylation and survival of eosinophils by GM-CSF [5]."
18466967
reach
"The findings of this study show that the effect of curcumol is similar to that of the JAK2/STAT3 signal inhibitor AG490 in reducing the phosphorylation of JAK2 and STAT3 in ectopic endometrial stromal cells.In animal experiments, curcumol showed a therapeutic effect equivalent to that of AG490, and curcumol can reduce the volume of ectopic lesions and atrophy of the endometrium of EMS model rats."
35279667
reach
"The pharmacologic inhibitor of JAK2, AG490, dose dependently blocked phosphorylation of JAK2 and expression of the downstream effectors, RhoA and Rho-kinase (XREF_SUPPLEMENTARY)."
24619965
reach
"Signal transducer and activator of transcription 3 (STAT3) is a cytoplasmic transcription factor, which can be activated by the phosphorylation of Janus kinase 2 (JAK2) [ 41 ]."
35550172
reach
"AG490 is a specific inhibitor of the JAK2/STAT3 signalling pathway that can effectively inhibit JAK2 phosphorylation, and subsequently inhibit STAT3 phosphorylation."
37160937
reach
"For example, CCL20-induced phosphorylation of JAK2 and STAT3 may be inhibited by a specific JAK2 inhibitor.59 Colorectal Cancer."
35241923
reach
"Treatment with angiotensin-(1–7) modulates, through the angiotensin II type 1 receptor, the insulin pathways, as it can provoke phosphorylation of Janus kinase 2 (JAK2) and insulin receptor substrate [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
18417117
reach
"An additional mechanism of action of angiotensin-(1–7) that might be of importance is modulation of insulin pathways by angiotensin-(1–7) via the angiotensin II type 1 receptor, leading to phosphoryla[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
18417117
reach
"After binding between leptin and LepRb in liver cells, intracellular signaling phosphorylation and activation of Janus kinase 2 (JAK2) are initiated."
38928125
reach
"Cbl mediated K63 linked ubiquitination of JAK2 enhances JAK2 phosphorylation and signal transduction."
28676638
reach
"It was noteworthy that both M2h and M6a regulated signal transducer and activator of transcription 3 (STAT3) signal pathway through inhibiting phosphorylation of Janus Kinase 2 (JAK2) and STAT3, and simultaneously increasing the protein level of downstream cyclin p21."
34874105
reach
"As for the protective mechanism, the iridoid glycoside could induce the phosphorylation of Janus kinase 2 (JAK2) in addition to the signal transducers and activators of transcription 3 (STAT3)."
28994736
reach
"AG490, a specific JAK2 antagonist, could significantly inhibit the phosphorylation of JAK2 (Figure  S8E )."
39031684
reach
"It is interesting for us to observe that inhibition of JAK2 activity by Ruxolitinib inhibits JAK2 phosphorylation but does not cause a reduced 5-LO expression, suggesting that JAK2V617F stimulates 5-LO expression independently of its kinase activity."
27784744
reach
"AG490 is an inhibitor of JAK2, which reduced the phosphorylation of JAK2 and STAT3 (Figure 2D)."
36926276
reach
"We performed immunohistochemical staining to study the expression levels of anti-proliferative markers JAK2, STAT3 and their phosphorylated version p-JAK2, p-STAT3 in the experimental groups ( Fig. 6 [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
29229353
sparser
"JAK2 is auto-phosphorylated and phosphorylated JAK2 then trans-phosphorylated JAK1."
19576750
reach
"Both JAK2 V617F and JAK2 exon 12 mutations are located in the JH2 psuedokinase domain, resulting in constitutive phosphorylation of the JAK2 kinase domain."
28402164
reach
"Involvement of JAK2 in receptor cross-talk recently reported that estrogen inhibits GH signaling by repressing GH-induced JAK2 phosphorylation [24] ."
15304355
reach
"IL-23 promotes signal transducer and transcriptional activator 3 (STAT3) phosphorylation by Janus kinase 2 (JAK2) and tyrosine kinase 2 (TYK2) by binding to its receptor IL-23R."
33597953
reach
"The levels of miR-122-5p, suppressor of cytokine signaling-1 (SOCS1), phosphorylation of Janus kinase 2 (p-JAK2), and signal transducers and activators of transcription (p-STAT3) in the myocardial tissues of mice were measured."
36882114
sparser
"In addition, the JAK2 inhibitor AG490 (5 μM) markedly ameliorated IRI-induced phosphorylation of JAK2 and STAT3 ( Fig. 2 H) as well as the upregulation of IRF-5 at both the mRNA ( Fig. 2 G) and the pr[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
28818665
reach
"It has been shown that GM-CSF and IL-5 transmit anti-apoptotic signals in eosinophils, Itsuo Iwamoto et al further found that activation of the JAK2-STAT5 pathway plays a key role in the anti-apoptotic signaling of GM-CSF in human eosinophils, and that the JAK2 blocker AG-490 inhibits JAK2 phosphorylation and eosinophil survival via GM-CSF."
37565871
sparser
"Additionally, we examined the expression of total JAK2 and phosphorylated JAK2, and total STAT3 and phosphoryated STAT3 after DXM, IL-6 and AG490 treatment."
23871159
reach
"For example, in our rule-based signaling model, the rate of IL-6 receptor-dependent, JAK2-mediated STAT1 activation (il6_jak2_med_STAT1_act) could represent changes in JAK2 phosphorylation and subsequ[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
38198893
sparser
"In addition, we measured the expression of JAK2 and phosphorylated JAK2, STAT3 and phosphorylated STAT3 after treating both cell lines with the combination of DXM and AG490, and we could not detect significant change in the expression of these proteins compared with AG490 alone (data not shown)."
23871159
reach
"JAK2 is activated when a GH molecule binds to a dimer of the GH receptor and JAK2, which promotes the phosphorylation of both JAK2 and the GH receptor."
25655275
reach
"Pretreatment of macrophages with AG490, a specific inhibitor of JAK2, significantly inhibited GH-induced phosphorylation of JAK2."
19250698
reach
"In addition to AG490, other inhibitors of JAK2/STAT3 had a reversal effect on cartilage degeneration, for instance, WP1066 was identified as a JAK2/STAT3 inhibitor, which rescued the IL-6-induced phosphorylation of JAK2 and STAT3 levels."
37013568
reach
"Subsequently, membranes were incubated overnight at 4 ​°C in 5 ​% bovine serum albumin/TBS-T with primary antibodies raised against the following targets: Cyclin D1 [Cell Signaling Technologies (CST) # #2978; 1:500]; STAT3 phosphorylated at Tyr705 (anti-pSTAT3; CST #9131S; 1:1000) and total STAT3 (CST #4904S; 1:6000); JAK2 phosphorylated at Tyr1007/1008 (anti-pJAK2; CST; 1:400) and total JAK2 (1:2000); ICER (Millipore/Sigma #SAB2500271; 1:100)."
39643584
sparser
"Here we show that GH binding promotes association of JAK2 with GHR, activation of JAK2, and tyrosyl phosphorylation of both JAK2 and GHR."
8343952
reach
"The classical intracellular signaling induced by GH is the phosphorylation of Janus kinase 2 (JAK2), with subsequent phosphorylation of the signal transducers and activators of transcription (STATs)."
31652811
reach
"GH elicits intracellular signaling through specific GH-receptors (GHRs) (Figure 2), which are transmembrane proteins that dimerize after GH binding and induce activation and phosphorylation of Janus kinase 2 (JAK2) [40]."
37373068
reach
"These results implied that compound 41 preferentially inhibited STAT3 phosphorylation with a good selectivity.Given that the suppression of STAT3 phosphorylation could be resulted from the loss of ups[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
38704936
reach
"For example, IL-12 binds to IL-12 receptors (IL-12R) to promote the transphosphorylation of Janus kinase 2 (JAK2) and tyrosine kinase 2 (TYK2), which activates the translocation of signal transducer and activator of transcription 4 (STAT4) homodimer into the nucleus where they bind to STAT binding sites in the interferon (IFN)-γ promoter leading to M1 polarization [144,145]."
39000385
reach
"Taken together, these data showed that the JAK2 associated cytokines including IL-6 and G-CSF may stimulate JAK2 phosphorylation to activate p-STAT3, indicating an association with disease severity and supporting its development of JAK2 inhibitor as a potential therapeutic agent for CRS."
| PMC
sparser
"The c-Mpl dimer is capable of inducing the phosphorylation of the Janus kinase (JAK) family of proteins, particularly JAK2, and then activated JAK2 phosphorylates transcription factors STAT3 and STAT5[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
28235674
reach
"The selective inhibitor of JAK2 and STAT3 signalling AG490 significantly suppressed JAK2 and STAT3 phosphorylation as well as VEGF expression."
18798867
sparser
"No significantly different expression was seen for JAK2 and phosphorylated JAK2 in any of the investigated diseases."
37624299
reach
"EGCG suppresses breast cancer progression through the tight binding of EGCG to signal transduction activator proteins of transcription 1 (STAT1) by its three hydroxyl groups of the B ring and one hydroxyl group of the D ring; this bond leads to the blockage of the phosphorylation of STAT1 by Janus Kinase 2 (JAK2) and inhibition of its carcinogenic effects since STAT1 in cancer cases can act as an oncogenic protein."
35664773
reach
"This effect is likely associated with stimulated signaling of the phosphoinositide-3-kinase (PI3K)/AKT/m-TOR pathway and phosphorylation of Janus kinase 2 (JAK2)/STAT3, resulting in proliferation, migration, and phenotype switch of vascular smooth muscle cells from a contractile to a synthetic state by elevating the mRNA and protein expression of matrix metalloproteinase 2 and 9 while reducing peroxisome proliferator-activated receptor-γ [142, 143]."
30302423
sparser
"JAB has recently been identified as a regulator of JAK2 phosphorylation and activity by binding phosphorylated JAK2 and inducing its degradation."
10975987
reach
"JAK2 exon 12 mutations lead to increased phosphorylation of JAK2 and STAT compared to the JAK2 V617F mutations, and result in cytokine-independent activation of JH1 [26]."
31778606
reach
"Also, the inhibition of JAK2 activation in Hs578T and SUM149 cells by the JAK2 inhibitor AG490 significantly reduced JAK2 and STAT3 phosphorylation and Twist-1 expression (XREF_FIG)."
27654855
reach
"Overexpression of JAK2 induced an auto- or trans-phosphorylation of JAK2 which was further enhanced by IFN-gamma treatment as determined a p-JAK2-specific antibody (XREF_FIG)."
21700930
sparser
"Xie et al. [ xref , xref ] have reported that JAK2 and ABL bonding could elicit JAK2 phosphorylation, which was not affected by BCR-ABL tyrosine kinase inhibitors, such as imatinib."
38716474
reach
"As expected, JAK2 overexpression increases JAK2 phosphorylation, combined with elevated STAT3 phosphorylation."
35843176
reach
"Degradation of ABCA1 is also suppressed by the COP9 signalosome, 46 because this signalosome binds to ubiquitinated ABCA1 to release ubiquitin.ABCA1 is phosphorylated by protein kinase A (PKA), protei[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
35063134
reach
"Activation and phosphorylation of STAT5 by JAK2 is thought to require binding of JAK2 through its FERM domain to a growth factor receptor ( Funakoshi-Tago et al., 2006; Wernig et al., 2008 )."
19878867
reach
"The Jak2 kinase inhibitor, AZD1480, 64 previously shown to inhibit Stat5a/b signaling in PC cells, 38 suppressed Prl regulation of Jak2 phosphorylation (Supplemental Figure S1 A) and E-cadherin, N-cad[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
26362718
reach
"6 In murine models and patients with beta-thalassemia, erythroid precursors express elevated levels of the phosphorylated active form of Jak2 (pJak2), and other downstream signaling molecules that promote proliferation and inhibit differentiation of erythroid progenitor cells (XREF_FIG)."
22631035
sparser
"Once bound to Fpn, Jak2 is autophosphorylated and phosphorylated Jak2 then phosphorylates Fpn permitting it to be captured and internalized by clathrin-coated pits ( xref )."
22019085
reach
"To this end, AT1-R recruits and phosphorylates JAK2 and, based on the target cell, one of the STAT is phosphorylated by activated JAK2."
32392562
sparser
"qRT-PCR and western blotting results showed that TAB3 silencing and overexpression did not affect the levels of total JAK2 or phosphorylated JAK2 ( Fig. 6 B and C)."
32229191
reach
"The specific involvement of JAK2 agrees with the notion that STAT5 is a major target for JAK2 in hematopoietic cells and that activation of KIT by SCF causes JAK2 phosphorylation."
30948489
reach
"Indeed, coumermycin A1 (CA1), a JAK2 agonist, has been shown to induce JAK2 phosphorylation and activate the JAK2/STAT3 pathway (Gong et al., 2018)."
37143406
reach
"Previous studies have indicated that persistent JAK2 activation, transphosphorylation or enhanced JAK2 expression induced by the exposure to JAK2 inhibitor would lead to drug resistance [ 33–38 ]."
31299252
reach
"Western blotting was performed to determine the level of ACE2 phosphorylation of janus kinase 2 (JAK2) and signal transducer and activator of transcription 3 (STAT3)."
37584123
reach
"AG490 is a selective inhibitor of the JAK2/STAT3 signaling pathway that significantly reduces JAK2 and STAT3 phosphorylation in cerebral ischemia [50] , cerebral hemorrhage [51] , and subarachnoid hem[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
37925951
sparser
"EPO binding to the EPO-receptor triggers activation of JAK2 and phosphorylated JAK2 can bind to STAT5 wherein the JAK2-STAT5 complex translocates to the nucleus and induces expression of target genes xref including but not limited to IREB2 (Iron responsive element binding protein 2) and anti-apoptotic factors such as BCL-XL xref ."
29458727