IndraLab

Statements

reach
"This result shows that an early event in the MVA infection cycle, preceding viral DNA replication and late gene expression, is sufficient to trigger IkappaBalpha degradation."
19596385
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"The nature of the stimuli responsible for MVA mediated activation of IkappaBalpha degradation has yet to be determined."
19596385
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"The requirement for infectious virions, together with the ability of MVA to induce IkappaBalpha degradation in the presence of cycloheximide, implicate viral early RNAs as prime candidates for stimulating NF-kappaB activation."
19596385
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"One indication that MVA may have a greater capacity to initiate NF-kappaB activation than some of the other orthopoxviruses is that MVA induces IkappaBalpha degradation even in the presence of cycloheximide, whereas cowpox virus induces little if any IkappaBalpha degradation under similar conditions."
19596385
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"We and others have demonstrated that expression of the VAC K1L gene is sufficient to suppress MVA induced IkappaBalpha degradation and subsequent activation of NF-kappaB."
22534090
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"In addition, we have shown that the cowpox virus CP77 gene, which can functionally substitute for the K1L gene to permit replication of MVA in RK13 cells, also can suppress MVA induced degradation of IkappaBalpha."
19596385