IndraLab

Statements

PRMT3 methylates TP53. 7 / 8
| 2 5
sparser
"For example, H4R3 can be methylated by PRMT1, PRMT5, PRMT6, and PRMT7; xref – xref TP53 can be methylated by PRMT3 and PRMT5; xref , xref and H3R2 can be methylated by PRMT5, PRMT6, and PRMT7. xref , xref To further understand the roles of each PRMT in cell biology, highly selective and cell-active inhibitors of each PRMT are needed."
33591753
sparser
"Our study uncovered a novel aspect of the VHL-p53-ARF interaction, arginine methylation of p53 by VHL, ARF, and PRMT3."
21942715
sparser
"We found that p53 was asymmetrically di-methylated by PRMT3 in the presence of VHL and ARF."
21942715
reach
"For example, H4R3 can be methylated by PRMT1, PRMT5, PRMT6, and PRMT7; TP53 can be methylated by PRMT3 and PRMT5; and H3R2 can be methylated by PRMT5, PRMT6, and PRMT7."
33591753
sparser
"ARF disrupts the E3 ligase complex containing VHL and instead enhances its interaction with the arginine methyltransferase PRMT3 which methylates p53 [ xref ]."
33406607
sparser
"Further work is needed to elucidate the functional significance of p53 arginine methylation by PRMT3 in complex with VHL and ARF."
21942715
reach
"ARF disrupts the E3 ligase complex containing VHL and instead enhances its interaction with the arginine methyltransferase PRMT3 which methylates p53 [XREF_BIBR]."
33406607