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HIV-1 activates USP18. 4 / 4
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"Since USP18 is induced by HIV-1 in iMacs in a similar manner as MDMs , we concluded that iMacs are a better model for studying USP18 knockout / knockdown than THP-1 cells ."
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"Indeed , USP18 + / + iMacs support HIV-1 replication and USP18 is induced by HIV-1 in these cells ( Figs ."
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"We next determined if iMacs can support HIV-1 replication as previously reported 48 and if USP18 is induced by HIV-1 in iMacs ."
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"Here , we demonstrate that USP18 expression is induced by HIV-1 in a T1 IFN-dependent manner ."
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