IndraLab

Statements

KCNMA1 activates emodepside. 3 / 3
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"The finding that expression of slo-1 from different nematode species restored the susceptibility to emodepside in the slo-1 (js379) mutants emphasises that the mode of action is most likely conserved between these species."
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"The expression of slo-1 in slo-1 (js379) animals from the pan-neuronal promoter snb-1 XREF_BIBR, XREF_BIBR and the muscle cell specific promoter myo-3 XREF_BIBR, XREF_BIBR, either in combination or separately, restored emodepside susceptibility to different degrees XREF_BIBR."
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"Expression of A. caninum slo-1 from the C. elegans slo-1 promoter (XREF_FIG) showed a marked susceptibility to emodepside that was equivalent to N2 wild-type worms : worms expressing the parasite slo-1 from the C. elegans slo-1 promoter in slo-1 (js379) animals fully restored susceptibility to emodepside as revealed by the absence of any significant differences in top and bottom values, Hill slope or EC 50 (XREF_TABLE)."
21490955