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LEP activates KCNMA1. 14 / 14
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"Here we show that BK channel activation by leptin is dependent on the actin cytoskeleton, as it is prevented by actin filament stabilization and mimicked by actin disruption."
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"However, in contrast to the present study, a PI 3-kinase driven process mediates actin filament disruption and BK channel activation by leptin (O'Malley et al, 2005; Shanley et al, 2002a,b)."
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"In parallel with the actions of leptin on K ATP channels (Harvey et al., 2000b), the ability of leptin to modulate BK channel activity requires stimulation of a PI 3-kinase-driven process (Shanley et [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Single-channel recordings in ' perforated microvesicles ' confirmed that leptin increased BK channel open probability without altering its unitary conductance."
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"Leptin induced BK channel activation in neurons has been first proposed by XREF_BIBR; XREF_BIBR) to explain the ability of this hormone to inhibit hippocampal neurons excitability."
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"As BK channel activation by leptin involves a membrane-delimited process ( xref ), and leptin driven PI 3-kinase activation results in a localized, membrane-associated increase in phosphatidylinositol-3,4,5-triphosphate (PtdIns(3,4,5)P 3; xref ), leptin signaling via this route is likely to result in a highly compartmentalized reorganization of actin filaments."
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"Here we show that BK channel activation by leptin is dependent on the actin cytoskeleton, as it is prevented by actin filament stabilization and mimicked by actin disruption."
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"Therefore, in the present study, the neuroprotective potential of BK channel activation by leptin and the underlying molecular mechanism(s), have been assessed in cortical neurons exposed to the ionotropic glutamate receptor agonist N-methyl-D-Aspartate (NMDA), a classical excitotoxic insult."
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"Therefore, in the present study, the neuroprotective potential of BK channel activation by leptin and the underlying molecular mechanism (s), have been assessed in cortical neurons exposed to the ionotropic glutamate receptor agonist N-methyl-D-Aspartate (NMDA), a classical excitotoxic insult."
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"As BK channel activation by leptin involves a membrane delimited process, and leptin driven PI 3-kinase activation results in a localized, membrane associated increase in phosphatidylinositol-3,4,5-triphosphate (PtdIns (3,4,5) P 3; XREF_BIBR), leptin signaling via this route is likely to result in a highly compartmentalized reorganization of actin filaments."
17618127
sparser
"As BK channel activation by leptin involves a membrane-delimited process (Shanley et al, 2002a), and leptin driven PI 3-kinase activation results in a localised, membrane-associated increase in phosphatidylinositol-3,4,5-triphosphate (PtdIns(3,4,5)P 3; O'Malley et al, 2005), leptin signaling via this route is likely to result in a highly compartmentalized re-organisation of actin filaments."
17618127
sparser
"However, in contrast to the present study, a PI 3-kinase driven process mediates actin filament disruption and BK channel activation by leptin ( xref )."
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"Thus, it is conceivable that BK channel activation by leptin regulates the level of hippocampal excitability."
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"In conclusion, our results suggest that leptin-dependent BK channel activation is a fundamental step in the neuroprotective effects triggered by this adipokine against NMDA-induced cortical neuronal degeneration."
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