IndraLab

Statements

ATM phosphorylates PAN2 on S1003. 4 / 4
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biopax:phosphositeplus
No evidence text available
sparser
"In addition, USP52 is phosphorylated by ATM at Ser-1003 after DNA damage, which enhances the catalytic activity of USP52."
33097710
sparser
"Our results suggest that the phosphorylation of USP52 on Ser-1003 by ATM increases the activity of USP52 to deubiquitinate CtIP and promote DNA end resection and HR repair."
33097710
signor
"Here, we identify that USP52 directly interacts with and deubiquitinates CtIP, thereby promoting DNA end resection and HR. Mechanistically, USP52 removes the ubiquitination of CtIP to facilitate the phosphorylation and activation of CtIP at Thr-847. In addition, USP52 is phosphorylated by ATM at Ser-1003 after DNA damage, which enhances the catalytic activity of USP52."
33097710