IndraLab

"In contrast to SV40 sT and MCV LT, MCV sT exhibits oncogenic activity: it transforms rodent fibroblasts and promotes serum-independent growth of human fibroblasts. xref This is because MCV sT functions differently from SV40 sT; MCV sT promotes eukaryotic translation initiation factor 4E-binding protein 1 hyperphosphorylation and cap-dependent translation in a PP2A-independent manner, xref whereas SV40 sT induces dephosphorylation of 4E-binding protein 1 in a PP2A-dependent manner and inhibits cap-dependent translation. xref Moreover, MCV sT suppresses the activity of the E3 ubiqitin ligase SCF Fbw7 , which degrades MCV LT, and stabilizes MCV LT through its LT-stabilization domain; xref SV40 sT does not have an LT-stabilization domain."