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USP8 increases the amount of NRG. 1 / 1

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"Mechanistically, we found that USP8 increased the expression of neuregulin receptor degradation protein-1 (Nrdp1), potently downregulated the expression of TLR4 and myeloid differentiation primary response protein 88 (MyD88) protein, and inhibited the phosphorylation of IkappaB kinase (IKK) beta and kappa B-alpha (IkappaBalpha), thereby reducing nuclear translocation of p65 by inhibiting the activation of the nuclear factor-kappaB (NF-kappaB) signaling pathway in LPS induced mice."

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IndraLab

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USP8 increases the amount of NRG. 1 / 1

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