IndraLab

Statements

MTOR phosphorylates EIF4EBP1 on T45. 11 / 12
3 | 3 4 1
rlimsp
"Mutational analysis of sites in the translational regulator, PHAS-I, that are selectively phosphorylated by mTOR. Results obtained with PHAS-I proteins having Ser to Ala mutations in the five known phosphorylation sites indicate that mTOR preferentially phosphorylates Thr36 and Thr45."
10405182
signor
"In response to insulin and nutrients, mTORC1, consisting of mTOR, raptor (regulatory-associated protein of mTOR), and mLST8, is activated and phosphorylates eukaryotic initiation factor 4E-binding protein (4EBP) and p70 S6 kinase to promote protein synthesis and cell size."
17510057
sparser
"The present study has confirmed that mTOR (or a tightly associated kinase) phosphorylates 4E-BP1 at T 36 and/or T 45 and has identified an mTOR-associated kinase which phosphorylates 4E-BP1 within a[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
10471835
signor
"Specifically as part of mTORC1, mTOR directly phosphorylates the ribo- somal protein S6 kinases (S6K1 and S6K2) and the eukaryotic initiation factor 4E (eIF4E)-binding proteins (4E-BP1 and 4E-BP2), both of which control specific steps in the initiation of cap-dependent translation"
20670887
signor
"Mtorc1 promotes protein synthesis by phosphorylating the eukaryotic initiation factor 4e (eif4e)- binding protein 1 (4e-bp1) and the p70 ribosomal s6 kinase 1 (s6k1). Raft1 phosphorylation of 4e-bp1 on thr-36 and thr-45 blocks its association with the cap-binding protein, eif-4e,in vitro. in response to insulin and nutrients, mtorc1, consisting of mtor, raptor (regulatory-associated protein of mtor), and mlst8, is activated and phosphorylates eukaryotic initiation factor 4e-binding protein (4ebp) and p70 s6 kinase to promote protein synthesis and cell size."
9465032
sparser
"Recent findings suggests that Thr36 and Thr45 in PHAS-I are preferentially phosphorylated by mTOR [14] ."
10405182
sparser
"mTAb1-activated mTOR phosphorylated Thr36, Thr45, Ser64, Thr69, and Ser82 in PHAS-I. All five of these sites fit a (Ser/Thr)-Pro motif and are dephosphorylated in response to rapamycin in rat adipocytes."
9405468
reach
"A second major target of mTOR is 4E-BP1, which is directly phosphorylated by mTOR at T36 and T45 [XREF_BIBR]."
26985829
reach
"MTOR readily phosphorylated T36 PHAS-I and T45 PHAS-I under conditions in which S64 PHAS-I, T69 PHAS-I, and S82 PHAS-I were not significantly phosphorylated."
10405182
reach
"RAFT1 phosphorylation of 4E-BP1 on Thr 36 and Thr 45 blocks its association with the cap binding protein, eIF-4E, in vitro, and phosphorylation of Thr 45 seems to be the major regulator of the 4E-BP1-eIF-4E interaction in vivo."
9465032
sparser
"RAFT1 phosphorylation of 4E-BP1 on Thr-36 and Thr-45 blocks its association with the cap-binding protein, eIF-4E, in vitro, and phosphorylation of Thr-45 seems to be the major regulator of the 4E-BP1-eIF-4E interaction in vivo."
9465032