IndraLab

Statements

CYLD activates TP53. 6 / 7
| 1 5
reach
"In addition, overexpression of HA-CYLD diminished the ubiquitination and increased the stabilization of endogenous p53 in CpT treated HCT116 cells (XREF_FIG)."
27561390
reach
"Moreover, CYLD was predicted to regulate p53 in an unbiased bioinformatics approach aiming to build a functional human protein interaction network by combining protein interaction, gene expression and gene ontology annotations with genome-wide cancer data sets XREF_BIBR, further supporting that regulation of p53 signalling by CYLD is functionally relevant for human cancer."
27561390
reach
"Recently, CYLD was shown to promote DNA damage induced p53 stabilization and activation in epithelial cells and inhibit chemical carcinogen induced intestinal and skin tumorigenesis [XREF_BIBR]."
28031783
reach
"Additionally, CYLD upregulated p53 by about 2-fold, which was diminished by c-Jun and MKK7 (XREF_FIG)."
22832488
reach
"We found that HA-CYLD expressed in HEK-293T cells co-immunoprecipitated with endogenous p53 or overexpressed GFP-p53 in reciprocal IPs and that this interaction was enhanced after DNA damage (XREF_FIG)."
27561390
eidos
"Mechanistic dissection showed that CYLD stabilized p53 and facilitated its nuclear translocation , thereby enhancing p53 activity by removing K63-linked and K48-linked ubiquitin chains of p53 , which can bind to the PFKFB3 promoter and inhibit its transcription ."
35131382