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TP53 binds HIF1A and MDM2. 7 / 7
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"Interestingly, HIF-1α also binds to the p53-binding site in MDM2, and Nutlin-3 was shown to block the MDM2-HIF-1α interaction, leading to the decreased transcriptional activity of HIF-1α and the down-regulation of its target gene VEGF under conditions of normoxia or hypoxia ( xref )."
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"A ternary complex between p53, HIF-1α, and MDM2 was proposed to promote pVHL-independent degradation of HIF-1α xref ."
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"Mdm2-mediated binding of p53 to HIF-1α causes ubiquitination and degradation of HIF-1α [19,28] ."
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"Conversely, p53-independent binding of MDM2 to HIF-1α was associated with the increase in HIF-1α protein content ( xref ), warning that the role of MDM2 in HIF-1α regulation might be more ambiguous than initially described."
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"MDM2-mediated interaction between p53 and HIF1α affecting their stability and activity has been reported xref , xref ."
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"Competition between p53 and HIF-1 for the coactivator p300 [17] as well as MDM2-dependent degradation of HIF-1α via the formation of a complex containing p53, HIF-1α and MDM-2 [18] may explain t[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Mayo and colleagues used mapping and competition studies to show that HIF-1α binds the p53-binding domain of MDM2 [ xref ]."
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