IndraLab

Statements

Glyburide inhibits NLRP3. 165 / 165
| 2 163
reach
"This possibility is supported by a preliminary study, in which we found that a long-term treatment of glyburide to inhibit NLRP3 did not extend the survival of M. tuberculosis infected mice (data not shown)."
21740493
reach
"Glyburide inhibits the Cryopyrin / Nalp3 inflammasome."
22612568
reach
"Interestingly, HIV-induced podocyte pyroptosis could be partially inhibited by Tempol (a superoxide dismutase mimetic agent) and by glyburide (an inhibitor of potassium efflux or NLRP3 protein)."
26683666
reach
"It has been demonstrated that Glyburide can inhibit NLRP3 inflammasome, but not NLRC4 or AIM2 [XREF_BIBR]."
33803783
reach
"In 2009, Lamkanfi and colleagues have identified that glyburide is able to inhibit NLRP3 activation in murine and human macrophages ( Lamkanfi et al., 2009 )."
31477246
reach
"Liu and colleagues have revealed that glyburide treatment inhibits NLRP3 activation in colon tissue and alleviates chronic colitis in interleukin (IL)-10 deficient mice ( Liu et al., 2017 )."
31477246
reach
"Likewise, another biaryl compound, glyburide, with an intrachain and a sulfone group, also inhibits NLRP3 in spite of its main therapeutic indications toward type 2 diabetes [14]."
35566202
reach
"For instance, glybenclamide (aka glyburide), which blocks potassium efflux and therefore NLRP3 inflammasome activation, was shown to significantly reduce colitis in Il10 -/- mice as well as the expres[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
29433944
reach
"Furthermore, to explore the underlying molecular mechanisms of ZnO-NP-induced ALI, N-acetyl-L-cysteine (a ROS scavenger), Cyclosporin A (an inhibitor for mitochondrial depolarization) and Glibenclamide (an inhibitor for NLRP3 inflammasome activity) were used to pre-treat A549 "
37979646
reach
"Glyburide (glibenclamide), a sulfonylurea drug used for the treatment of type-2 diabetes, is known to inhibit ATP sensitive K + channels and can thus prevent NLRP3 inflammasome activation."
26279628
reach
"The sulfonylurea drug glyburide, usually used clinically to treat type II diabetes, is a non selective antagonist of NALP3 and could prevent activation of the NALP3 inflammasome and crystal induced IL-1beta secretion."
30186184
reach
"Glibenclamide inhibited NLRP3 inflammasome via upstream inhibition of the inflammasome and downstream blockade of the P2X7 receptor, which then reduced NLRP3 inflammasome mediated caspase-1 activation and inhibited the maturation of IL-1beta [XREF_BIBR]."
29178967
reach
"Lamkanfi et al. demonstrated that the ability of glyburide to inhibit NLRP3 activation is independent of its inhibitory effect on K channels and speculated that glyburide acts the upstream of NLRP3 and the downstream of P2X7 receptor (26)."
35463001
reach
"In addition to glyburide, which inhibits this momentous NLRP3 in the progression of autoimmune disorders, we loaded a group of DCs with insulin as an autoantigen."
37979448
reach
"Glyburide also inhibits NLRP3 inflammasome by inhibiting ATP-sensitive potassium channel and thus disturbs ASC aggregation59)."
33678767
reach
"Antioxidants and glyburide block upstream signaling of the NLRP3 inflammasome in vitro."
25596299
reach
"NLRP3 inflammasome signaling pathway was augmented by LPS but suppressed by glyburide."
27614764
reach
"Glyburide, an antidiabetic drug, can block NLRP3 inflammasome activation by inhibiting ATP sensitive K+ channels XREF_BIBR."
32505910
reach
"Previous study demonstrated that glibenclamide was able to suppress NALP3 activation independently of K ATP [XREF_BIBR]."
25077824
reach
"Although, the administration of glyburide inhibited NLRP3 inflammasome, at moderate doses would cause lethal hypoglycemia in mice [62,63]."
37507935
reach
"Interestingly, Glyburide, a frequently used sulfonylurea drug for the treatment of type 2 diabetes, has been shown to inhibit the NLRP3 inflammasome ( Lamkanfi et al., 2009; Masters et al., 2010 ), an[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
22225872
reach
"In addition, a study has reported that glibenclamide inhibits the NLRP3 inflammasome and effectively reduces edema development [201]."
34059091
reach
"Glyburide (Gly) could inhibit NLRP3 inflammasome, as well as could be treated with Type 2 diabetes as a common medication."
34037304
reach
"Results suggested glyburide might inhibit NLRP3 inflammasome to attenuate inflammation related lung tumorigenesis caused by intratracheal instillation of B (a) p/LPS in non diabetes mice."
34037304
reach
"Glyburide, a type 2 diabetes drug, has been shown to specifically inhibit the NLRP3 inflammasome in response to microbial and crystalline stimuli XREF_BIBR."
25254654
reach
"In this work, we found that glibenclamide could inhibit Nalp3 inflammasomes and Caspase-1 induced by LPS+ high glucose stimulation in cultured peritoneal macrophages, suggesting that the effects of glibenclamide on prevention of serum IL-1beta and TNF-alpha might be related to inhibiting Nalp3 inflammasomes and Caspase-1."
25077824
reach
"The mechanism how glibenclamide inhibits NALP3 inflammasomes and suppresses IL-1beta secretion is an intriguing question."
25077824
reach
"The effects of the caspase‐1 inhibitor ZYVAD‐fmk or NLRP3 antagonist glyburide, and treatment with S1P or the S1P receptor regulator FTY720, with or without exposure to cigarette smoke extract were investigated.In alveolar macrophages, cigarette smoke induced increased intracellular expression of IL‐1β (~15%, p<0.05 on pooled data from 3 donors), with particulate staining for cleaved IL‐1β increased both inside and outside the cell (5 fold, p<0.001 on pooled data)."
28299871
reach
"Lamkanfi et al. demonstrated that glibenclamide could inhibit the assembly of the NALP3 inflammasomes in response to stimulation with lipopolysaccharide (LPS) and adenosine triphosphate (ATP) [XREF_BIBR]."
25077824
eidos
"Although glyburide potently inhibits NLRP3 activation in vitro , it requires high doses in vivo and the mechanism of action is unknown ."
31036962
reach
"Glyburide and fluoxetine inhibited NLRP3 inflammasome activation in hippocampi via downregulating TXNIP."
29084550
reach
"Glyburide and fluoxetine impeded activation of NLRP3 inflammasome in pancreas by suppressing upstream molecule TXNIP."
29084550
reach
"The inhibition of NLRP-3 by glibenclamide is initiated by inhibition of K ATP channel activation [11,23] ."
24291534
reach
"Glyburide, which specifically inhibits NLPR3 inflammasome activation [XREF_BIBR], was used to inhibit NLRP3, and capase-1 inhibitor YVAD was used to inhibit caspase-1."
27250627
reach
"Glyburide and YVAD significantly inhibited the activation of NLRP3 inflammasome and the production of IL-1beta stimulated by anti-dsDNA antibodies."
27250627
reach
"Glibenclamide (glyburide), an ATP-sensitive K channel inhibitor used clinically to treat type 2 diabetes, has been shown to inhibit NLRP3 in vitro."
35952982
reach
"It has been observed that glyburide, a drug for the treatment of diabetes classified as a sulfonylurea, may block the activation of the NLRP3 inflammasome through the inhibition of ATP sensitive K+ channels."
33466589
reach
"IL-1beta secretion was not affected by treatment with the NLRP3 inhibitor glyburide XREF_BIBR or parthenolide, which has also been shown to inhibit NLRP3 XREF_BIBR."
22216309
reach
"Glyburide, a potassium channel inhibitor, could block the outflow of potassium ions and inhibit the assembly of the NLRP3 inflammasome (Zahid et al., 2019)."
34869071
reach
"Glyburide and parthenolide both inhibited NLRP3 activation by LPS and ATP (data not shown)."
22216309
reach
"Glyburide (International Nonproprietary Name : glibenclamide), an antidiabetic sulfonylurea drug, inhibits NLRP3 inflammasome activation by several stimuli, without affecting the NLRC4 or NLRP1 inflammasomes [XREF_BIBR]."
25152324
reach
"Glyburide inhibits the Cryopyrin and Nalp3 inflammasome."
22917079
reach
"Glyburide inhibits the cryopyrin and Nalp3 inflammasome."
30589456
reach
"For inhibitor experiments, glyburide (100 mumol/L) and Z-YVAD-FMK (2 mumol/L) were added 30 minutes before PM 10 exposure to inhibit the NLRP3 inflammasome 38 or caspase-1, respectively."
22227418
reach
"A study [123] found that glibenclamide combined with ATP-sensitive K channel could inhibit NLRP3."
36620089
reach
"Glyburide, an ATP-sensitive potassium channel inhibitor, can suppress the NLRP3-dependent maturation of pro-caspase-1 and pro-IL-1 β [ 85 ]."
30641048
eidos
"( 4 ) Glyburide that inhibits NALP3 , which is a component of the inflammasome and coded by the NLRP3 gene [ 58 ] ."
31018556
reach
"In summary, XREF_FIG provides two important pieces of information : first, that the NLRP3 inflammasome is more active in obese mice, as indicated by a more robust IL-1beta response; and second, that glyburide effectively inhibits the NLRP3 inflammasome, as evidenced by a significant reduction in IL-1beta release."
25152324
reach
"This is the first study demonstrating that experimental SAP in obese rodents can be mitigated using glyburide, which has been shown to inhibit the NLRP3 inflammasome."
25152324
reach
"This, in addition to the findings by the same group showing glyburide inhibits the inflammasome upstream of the NLRP3 subunit (likely through inhibition of K ATP channel mediated efflux of K +), provides strong evidence that glyburide is indeed specifically inhibiting NLRP3 inflammasome activation [XREF_BIBR]."
25152324
reach
"Inversely, KD-FANCC increased the expression of p-p38 and NLRP3, which were remarkedly decreased by treatment with BIRB 796 (Additional file 2: Figure S2B–D); however, NLRP3 inhibition by glyburide did not affect p38 phosphorylation, indicating that FANCC regulated NLRP3 expression via a p38-dependent way during inflammation (Fig. 2A–C)."
35659106
reach
"Glibenclamide (gli) blocks the assembling signal for NLRP3 activation by inhibiting the P2X7, a purinoceptor for ATP [14]."
38543085
reach
"A previous study revealed that glyburide could prevent PAMPs, DAMPs, and the crystal-induced activation of NLRP3 inflammasome in BMDMs, while it did not alter NLRP3 expression or suppress AIM2 or NLRC4, suggesting that glyburide suppressed NLRP3 upstream of ASC [88]."
38732221
reach
"Glibenclamide was also shown to inhibit activation of the NLRP3 inflammasome [XREF_BIBR]."
33456300
reach
"Prior evidence has indicated that NLRP3 could be selectively blocked by concentrated extracellular K+, glyburide, MCC950, minocycline and KD [78,79]."
36551161
reach
"Glibenclamide inhibits the function of nod-like receptor pyrin 3 (NLRP3) that is induced by SARS-CoV-2 invasion."
36858313
reach
"Therefore, glibenclamide inhibits the activation of NLRP3 inflammasome, lowers oxidative stress as well as the over-activation of microglial cells in the brain tissue and release of pro-inflammatory cytokines [40]."
36858313
reach
"To eliminate that adverse effect, an intermediate of glibenclamide, 16673-34-0, has been designed to inhibit the NLRP3 inflammasome [135]."
35042840
reach
"Similar results were obtained when glyburide instead of CASP1 inhibitor was used to block NLRP3 inflammasome XREF_BIBR, XREF_BIBR."
32332867
reach
"In addition, a small molecule intermediate in the synthesis of glyburide (i.e., the so called 16673-34-0 compound) was also able to inhibit the formation of the NLRP3 inflammasome [ 86 ]."
30641048
reach
"Furthermore, SARS-CoV-2-induced lytic cell death is reversed by the diabetes medicine glyburide, which abolishes the activation of the NLRP3 inflammasome."
34360684
reach
"These include small molecules such as MCC950 and β-hydroxybutyrate, which block the assembly of the inflammasome, and inhibitors of potassium efflux such as glyburide and tamoxifen, which prevent the [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
37481141
reach
"While glyburide effectively inhibits NLRP3 activation in vitro, the high doses required in vivo limit its usefulness as a treatment due to major adverse effects."
37175869
reach
"Glyburide, the most widely used sulfonylurea drug for type 2 diabetes in the US, inhibits the Nalp3 inflammasome."
22065079
reach
"Moreover, BBG inhibits P2X7R, which may alleviate symptoms of IIM by downregulating the NLRP3/IL-1β pathway, while glyburide suppresses NLRP3, which may reduce the inflammatory response by reducing IL[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
34116285
reach
"In 2009, Lamkanfi and colleagues linked sulfonylureas to NLRP3 when they demonstrated that glyburide specifically inhibited NLRP3 signaling [ 12 ]."
35513901
reach
"Plus, Glyburide has been assumed to block ATP-sensitive potassium channels and ATPase activity of NLRP3, but its inhibitory activity maybe more than that [ 92 ]."
32703754
reach
"Glombik et al [XREF_BIBR] observed that maternal diabetes causes the activation of NLRP3 inflammasome signaling by increasing the level of the NLRP3 protein subunit, and glyburide, as a NLRP3 inflammasome inhibitor, diminishes the level of NLRP3 protein and caspase-1 subunits, and has particular therapeutic value in anti- metabolic related inflammation."
33395071
reach
"Though indirect, the potency of glyburide for NLRP3 led to enthusiastic research on sulfonylurea derivatives and to the discovery of MCC950- a selective and direct inhibitor of NLRP3 that did not impact AIM2, NLRC4, or NLRP1 inflammasome signaling [191]."
33036374
reach
"Glyburide appears to inhibit the NLRP3 inflammasome and the subsequent IL 1betaactivation in macrophages."
32445957
reach
"This can be explained by the fact that Nlrp3 inflammasome inhibition by glibenclamide was only partial, as residual amounts of IL-1beta and cleaved caspase-1 were still detectable in myeloid cells (unpublished data)."
23980097
reach
"Glyburide reduced tumor proliferation in bladder and lung carcinoma by modulating the cell cycle and inhibiting the NLR family pyrin domain containing 3 (NLRP3) inflammasome [184]."
40227837
reach
"Glyburide reduced the activation of the cryopyrin inflammasome."
38882867
reach
"Interestingly, glibenclamide (also known as glyburide), a diabetes drug proposed as a novel treatment for acute brain injury due to its ability to inhibit the Sur1-Trpm4 channel involved in brain edema [XREF_BIBR], was also shown to inhibit the NLRP3 inflammasome [XREF_BIBR]."
25091898
reach
"NLRP3 inhibition by glyburide inhibits myocardial contractile dysfunction and decreases myocardial and circulating IL-1β, boosting the survival rate of mice.34 Artemisinin is a traditional Chinese medicine and natural product with significant antimalarial, anti-inflammatory, and immunoregulatory effects.92 Similarly, it decreases mortality rates, serum inflammatory cytokines, adhesion molecule levels, and neutrophil infiltration in the hearts of burn septic mice.65 Artemisinin decreases protein levels of NLRP3/caspase 1 and downregulates mRNA expression of IL-1β and IL-18 in burn sepsis serum-stimulated Raw 264.7 cells."
39967903
reach
"Glibenclamide decreases the protein and mRNA expression levels of NLRP3 and caspase-1 induced by OA."
31123394
reach
"We speculated that rather NLRP3 inflammasome which could be inhibited by the glibenclamide than TLR4 receptors, involved in OA-induced ALI."
31123394
reach
"However, the doses of glyburide used in vivo to inhibit NLRP3 are very high, which results in hypoglycaemia, so it is limited to treating T2D only [247] ."
35365780
reach
"Pharmacological inhibition of NLRP3 by glyburide blocks NLRP3 inflammasome activation in CFs34 (Figure 4)."
39967903
reach
"11 A great deal of evidence shows that glibenclamide has anti-inflammatory effect not only in respiratory, but also in digestive, urinary, heart and central nervous system diseases and ischemia-reperfusion injury.44–48 The mechanism of glibenclamide inhibiting NLRP3 activity is still unclear."
31123394
reach
"Dimethyl fumarate-mediated Nrf2/ARE pathway activation and glibenclamide-mediated NLRP3 inflammasome cascade inhibition alleviate type II diabetes-associated fatty liver in rats by mitigating oxidative stress and inflammation."
36999408
reach
"It was reported that glyburide prevents Nlrp3 inflammasome activation in vitro; XREF_BIBR however, the effects of GLP-1 receptor activation on the Nlrp3 inflammasome has not been reported before."
27547413
reach
"In addition, the anti-diabetic drug glyburide can inhibits NLRP3 and therefore may function partially via ani-inflammatory mechanisms."
23068074
reach
"Importantly, both indicators of neuroinflammation were blocked by glyburide, indicating their dependence on NLRP3."
32602164
reach
"This decrease was blocked by glyburide, demonstrating the central role of NLRP3 and suggesting that NLRP3 inhibitors may further help prevent BOO-induced neurodeterioration by suppressing negative changes in neuroplasticity."
32602164
reach
"Glyburide had no effect on NLRP3, caspase-1 and IL-1beta expression as compared with the control group, while the NLRP3, caspase-1 and IL-1beta were decreased by (20.49 +/-7.6)% (t = 2.862, P < 0.01), (32.94 +/-3.44)% (t = 4.154, P < 0.001) and (24.67 +/-5.29)% (t = 2.335, P < 0.05) in the PDGF+ glyburide group, respectively, as compared with the PDGF group."
28592027
reach
"Glyburide, a sulfonylurea, is reported to inhibit the activation of NLRP3 inflammation by blocking the ATP-sensitive K+ channels (KATP)[61]."
34754842
reach
"The use of glibenclamide and interference plasmids to inhibit NLRP3 inflammasome activation revealed that the number of CSFV virus gene copies and the virus titer after 24 and 48 h increased following CSFV infection in PBMCs, indicating that NLRP3 had a negative effect on CSFV replication."
30013955
reach
"For example, Liao et al., reported that glibenclamide was able to inhibit activation of the NLRP3 inflammasome in hypoxia-injured mice [ 33 ], while Makar et al., showed that glibenclamide suppressed [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
31811853
reach
"Glyburide inhibits NLRP3 inflammasome activity caused by islet amyloid polypeptide (IAPP), ATP, and nigericin."
33534121
reach
"Glibenclamide is known to block the NLRP3 (NACHT, LRR, and PYD domains containing protein 3) inflammasome, which has been implicated in the pathophysiology of EAE [XREF_BIBR]."
26581714
reach
"Glyburide, a drug commonly used in type 2 diabetes, can also prevent NLRP3 dependent IL-1beta production [XREF_BIBR]."
28192528
reach
"The decrease in nerve density was blocked by glyburide or anakinra, clearly implicating the NLRP3 pathway in denervation."
28984997
reach
"Nano molar concentration of MCC950, glyburide, sulofenur, glimepiride, gliquidone, or glisoxepide inhibits NLRP3 activation and stimulates insulin secretion in mouse pancreatic cells, indicating the dual effects (Hill et al., 2017)."
34539410
reach
"To further validate the role of NLRP3 inflammasome during HS induced cellular responses, cells were co-cultured with the NLRP3 antagonist glyburide or the caspase-1 specific inhibitor YVAD."
30611121
reach
"In 2009, Lamkanfi et al. showed that glyburide specifically inhibited NLRP3 signaling (Lamkanfi et al., 2009)."
39144618
reach
"This study revealed that glyburide inhibits NLRP3 inflammasome activation by various stimuli, thereby preventing secretion of IL-1beta [XREF_BIBR]."
20861596
reach
"Several studies report that Glyburide reduces a variety of NLRP3-dependent pathologies such as septic shock, bronchopulmonary dysplasia and Cutaneous leishmaniasis (119, 120, 122)."
36741414
reach
"Glyburide also inhibits NLRP3, caspase-1, and IL-1β in macrophages and may be used as an inflammasome inhibitor to treat NLRP3-related inflammatory diseases [188]."
39710713
reach
"The Nlrp3 inhibitor glibenclamide and the Raf kinase inhibitor protein (RKIP) have been demonstrated to protect the BBB and reduce cerebral edema by inhibiting Nlrp3 [51]."
39715736
reach
"Another inhibitor of NLRP3, the sulfonylurea diabetes drug glyburide, reduced IL-6 secretion by SARS-CoV-2-infected human monocytes ."
34373622
reach
"Glyburide inhibits the Cryopyrin and Nalp3 inflammasome."
19805629
reach
"In this study, we show that glyburide prevented activation of the Cryopyrin inflammasome by a variety of stimuli."
19805629
reach
"The type 2 diabetes drug glyburide also prevents activation of the NLRP3 inflammasome [XREF_BIBR]."
28473983
reach
"Similar to RIPK3 dependent IL-1beta activation in caspase-8 or IAP depleted macrophages, the caspase-1 and IL-1beta secretion (but not TNF secretion) observed in LPS treated Ripk1 -/- FLDMs was abrogated by glyburide inhibition of NLRP3 (XREF_FIG)."
25693118
reach
"Glyburide inhibits the Cryopyrin inflammasome downstream of the P2X 7 receptor."
19805629
reach
"Additionally, glibenclamide inhibited NLRP3 and caspase-1 expression [XREF_BIBR]."
28740332
reach
"Previous studies have shown that in conditions such as renal impairment (69), sepsis-induced myocardial injury (70), and asthma (71), glyburide reduces inflammation by inhibiting NLRP3 activation and decreasing levels of inflammatory mediators such as IL-1β and IL-18 (72)."
39723212
reach
"Glyburide and MCC950 were used to inhibit the NLRP3 inflammasome."
34631111
reach
"However, NLRP3 could also be inhibited by glyburide, dioscin, metformin and resveratrol, preventing the bone loss from the progress of pyroptosis."
36645574
reach
"Our results suggest that 200 μM glyburide significantly reversed the HKCA-induced upregulation of NLRP3 and pyroptosis-related proteins compared with those in the untreated group (Figures 6A–D)."
35463001
reach
"Collectively, these results indicate that glyburide inhibits engagement of the Cryopyrin inflammasome by diverse stimuli and that inhibition occurs downstream of the P2X 7 receptor (XREF_FIG)."
19805629
reach
"To explore whether N. caninum also induced NLRP3 inflammasome activation via K + efflux, glyburide, which inhibits the NLRP3 inflammasome by inhibiting K + efflux, was added to BMDMs."
30105037
reach
"The structure activity relationship experiments (XREF_FIG) suggest that glyburide inhibits the Cryopyrin inflammasome independently of SUR1 containing K ATP channels."
19805629
reach
"A sulfonylurea compound named glyburide, used for the treatment of type-II diabetes, was found to inhibit NLRP3 inflammasome at high concentrations in vitro."
35948198
reach
"Neither glyburide nor compound G1 reduced the ATPase activity of recombinant Cryopyrin (XREF_FIG; and Fig."
19805629
reach
"Collectively, these results demonstrate that glyburide acts upstream of Cryopyrin and downstream of the P2X 7 receptor to block Cryopyrin dependent inflammasome activation by PAMPs, DAMPs, and crystalline substances."
19805629
reach
"An interesting point in the relationship between inflammasome and metabolism is that glyburide, a well-known drug of sulfonylurea class for type 2 diabetes inhibits NLRP3 stimulation, which is independent of its effect on ATP sensitive K ATP channel."
21637386
reach
"In our study, we chose glibenclamide not only because of its protective role in neurological diseases by inhibiting K ATP channels, but also because that glibenclamide could abolish the activation of NLRP3 inflammasome in bone marrow derived macrophages (BMDMs) [XREF_BIBR], although the exact mechanism was not fully understood."
29178967
reach
"Glibenclamide Might Inhibit the Activation of NLRP3 Inflammasome."
28740332
reach
"Our results indicated that glibenclamide suppressed NLRP3, caspase-1, and IL-1beta in mice spinal cord in morphine tolerance."
29178967
reach
"Cai et al. reported that glyburide significantly inhibited high glucose plus LPS-induced elevation of NLRP3 and CASP1 proteins in peritoneal macrophages in vitro (37)."
35463001
reach
"Finally, specific FDA approved reagents that inhibit molecules involved in asbestos induced inflammation are available : anakinra, an IL-1beta receptor antagonist; infliximab, a chimeric human-mouse anti-TNF-alpha; etanercept, a soluble TNF receptor fusion protein; glyburide, that inhibits the NALP3 inflammasome [XREF_BIBR]."
26308799
reach
"Glibenclamide inhibited NLRP3 inflammasome activation and subsequently protected against organ inflammation and tissue damage either in a cerulean induced obese mouse model of SAP, or in an adenine-diet rat model of chronic kidney disease, or in a cyclophosphamide induced rat model of bladder inflammation, or in a lipopolysaccharide induced myocardial injury in streptozocin induced diabetic rats [XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR]."
28740332
reach
"However, the mechanism by which glyburide inhibits NLRP3 inflammasomes and suppresses IL-1β secretion has been suggested to be an is an intriguing question (37)."
35463001
reach
"However, the exact molecular target of glyburide inhibiting NLRP3 inflammasome has yet to be elucidated (37)."
35463001
reach
"Glyburide also suppressed inflammasome components, suggesting the pivotal role of the NLRP3 pathway in MTX treatment."
36785716
reach
"Glibenclamide abolished inflammasome activation in macrophages lacking K ATP channel subunits as well [XREF_BIBR]."
28740332
reach
"Finally, we treated monocytes and MDC with 100 muM glibenclamide, a sulfonylurea drug which inhibits NLRP3 activation but not NLRC4 activation [XREF_BIBR]."
28081233
reach
"Moreover, our study provided a clinically safe and effective hypoglycemic drug, glibenclamide, which inhibited HSP70 release by blocking K ATP channel and suppressed NLRP3 inflammasome activation, which consequently attenuated morphine tolerance."
29178967
reach
"For example, Glyburide can inhibit NLRP3 inflammasome mediated caspase-1 activation and both IL-1beta and IL-18 release 15."
22430788
reach
"Furthermore, glyburide impedes PAMP, DAMP, and crystal mediated NLRP3 inflammasome activation in bone marrow derived macrophages [XREF_BIBR]."
32693241
reach
"Glibenclamide reduces LPS-induced damage by streptozotocin in diabetic mice by inhibiting activation of NLRP3 inflammasome (147)."
36993972
reach
"In mouse models, glyburide effectively blocked NLRP3-dependent diseases and ameliorated LPS-mediated septic shock and bronchopulmonary dysplasia (Liao et al. 2015; Lamkanfi et al. 2009)."
38421496
reach
"Dwivedi et al. (148) also demonstrated that glibenclamide inhibits NLRP3 to reduce the levels of glucose, triglycerides, cholesterol, DNA damage, apoptosis, and inflammatory markers in T2DM mice by improving antioxidant status and upregulating the insulin signaling pathway."
36993972
reach
"Glyburide (glibenclamide), a sulfonylurea drug used for the treatment of type-2 diabetes, is known to inhibit ATP sensitive K + channels and can thus prevent NLRP3 inflammasome activation."
26279628
reach
"As was already demonstrated, IL-6 and NLRP3 vesicles can be regulated by MALAT1 and NEAT1, and the use of IL-6 and NLRP3 blockers such as tolimumab and glibenclamide can lower morbidity and death (Paniri and Akhavan-Niaki, 2020)."
37576600
reach
"Considering the issues mentioned above, it seems that NLRP3 inhibition by glyburide can be used as a promising strategy for the induction of TolDCs, so in this study, we treated human monocyte-derived[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
37979448
reach
"Glibenclamide reduces the neurotoxicity of 2,5-hexanedione in the spinal cord by inhibiting the NLRP3 inflammasome pathway (Hou et al., 2020)."
39101602
reach
"Glyburide was shown to potently block the activation of the NLRP3 inflammasome induced by PAMPs, DAMPs and crystalline substances [ 92 ]."
31228512
reach
"In fact, glyburide, which is used in the treatment of T2D, was found to inhibit NLRP3 inflammasome activity."
23276949
reach
"Glyburide blocks NLRP3 activation and secretion of IL-18 and IL-1β."
35682990
reach
"As shown in Fig. 7e–g, the secretion of IL-1β and IL-18 was also inhibited in glyburide-treated T2D mice, indicating that the activation of NLRP3 inflammasome was inhibited by glyburide in vivo, although glyburide didn’t directly inhibit NLRP3 protein ."
30291237
reach
"Consistently, glibenclamide also blocked the oligomerization of ASC (XREF_FIG) and the association of NLRP3 and ASC (XREF_FIG and XREF_SUPPLEMENTARY) in mouse BMDMs in response to 25-HC treatment."
27779191
reach
"In that work, DCs were incubated with Pb after being treated with NLRP3 inhibitor (3,4-methylenedioxy-beta-nitrostyrene (MNS), caspase-1 inhibitor (VX-765), and K + efflux inhibitor (glyburide inhibit[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
37979448
reach
"Anti-diabetic drug glibenclamide (GLB) possesses anti-inflammatory properties and inhibits NACHT, LRR, and PYD domains-containing protein 3 (NLRP3) inflammasome activation."
34664134
reach
"Glyburide was shown to inhibit the ATPase activity of NLRP3, but it is unclear whether other drugs from this class can act in a similar manner, and if this observation is related to the glyburide mediated inhibition of inflammasome formation."
27508077
reach
"Glyburide inhibits NLRP3 inflammasome activity."
33603747
reach
"Marchetti and colleagues designed a novel inhibitor 16673-34-0 derived from glyburide that selectively inhibits NLRP3."
35464402
reach
"Compound glyburide, which is known to inhibit NLRP3 function, blocked IL-1beta production because of M. tuberculosis and M. tuberculosis promoted necrosis (XREF_FIG)."
21740493
reach
"Lamkanfi et al. demonstrated that glyburide is able to inhibit assembly of the NLRP3 inflammasome in response to stimulation with lipopolysaccharide (LPS) and adenosine triphosphate (ATP) XREF_BIBR."
24147174
reach
"Glyburide has previously characterized to inhibit NLRP3 inflammasome complex [56] ."
35660098
reach
"To investigate the role of the NLRP3 inflammasome in LPS induced IL-1beta production by the CFs, the cells were transfected with siRNA, which was specific for NLRP3, or CFs were pretreated with glyburide (an inhibitor of NLRP3 inflammasomes) prior to the LPS challenge XREF_BIBR."
25216263
reach
"NLRP3 can be selectively blocked by concentrated extracellular K , MCC950, ketogenic diet, glyburide, and minocycline (Muñoz-Planillo et al., 2013; Wallisch et al., 2017)."
36467606
reach
"Glyburide, a K + channel blocker, also inhibited NLRP3 inflammasome in vitro, which appears to confirm the role of K + efflux."
29892295
reach
"β-Hydroxybutyrate, celastrol and glyburide inhibit the activation of NLRP3 inflammasome by inhibiting K channels."
39930811
reach
"In 2017, Liu and colleagues have further revealed that glyburide therapy inhibits NLRP3 activation in colon tissue and alleviates chronic colitis in interleukin (IL)-10 deficient mice ( Liu et al., 20[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
31477246
reach
"In human trophoblast cells, glibenclamide acts downstream of the P2X7 receptor and upstream of NLRP3, effectively blocking the activation of the NLRP3 inflammasome (74)."
37497237
reach
"To determine whether NLRP3 inflammasome is involved in islet cell death induced by hypoxia, NLRP3 inflammasome was inhibited by glyburide under hypoxia and cell death analyzed."
29941940
reach
"Likewise, a sulfonylurea drug Glyburide which is widely used for the treatment of Diabetes type 2, was also shown to inhibit the NLRP3 inflammasome."
32574259
reach
"Our results are in agreement with the study of Tschopp et al., who showed that NLRP3 inflammasome is expressed and inhibited by glyburide in murine islet cells 20."
29941940
reach
"Primarily acting by blocking the ATP sensitive K + channels (K ATP) in beta-cells of the pancreas, Glyburide was shown to act upstream and prevent NLRP3 inflammasome activation."
32574259
reach
"They demonstrated that glyburide acts upstream of Cryopyrin and downstream of the P2X7 receptor to block Cryopyrin-dependent inflammasome activation by PAMPs, DAMPs, and crystalline substances."
35844498
reach
"The sulfonylurea Glyburide inhibits ATP sensitive K + (K ATP) channels and has been shown to inhibit NLRP3 inflammasome activation, without affecting the NLRP1 or NLRC4 inflammasomes."
26024799
reach
"Additionally, glyburide can inhibit the NLRP3 inflammasome in cells infected with RNA viruses [131]."
34183243