IndraLab

Statements

RPS6KB1 phosphorylated on T390 is active. 5 / 5
5 |
signor
"We show that PHLPP preferentially dephosphorylates the hydrophobic motif T389 site in S6K1 in vitro"
21986499
signor
"We show that PHLPP preferentially dephosphorylates the hydrophobic motif T389 site in S6K1 in vitro"
21986499
signor
"Thr229 phosphorylation requires prior phosphorylation of the Ser/Thr-Pro sites in the autoinhibitory domain and Thr389 in the linker domain,[…] Moreover, in vitro mTOR directly phosphorylates Ser371, and this event modulates Thr389phosphorylation by mTOR, compatible with earlier in vivo findings."
11914378
signor
"Thr229 phosphorylation requires prior phosphorylation of the Ser/Thr-Pro sites in the autoinhibitory domain and Thr389 in the linker domain,[…] Moreover, in vitro mTOR directly phosphorylates Ser371, and this event modulates Thr389phosphorylation by mTOR, compatible with earlier in vivo findings."
11914378
signor
"Here we report the identification of ribosomal protein S6 kinase 1 (S6K1) as a novel substrate of PHLPP."
21986499