IndraLab

Statements

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"Mefenamic acid which belongs to fenamate group inhibits the NLRP3 inflammasome by inhibiting efflux of chloride ions and influx of calcium ions through blocking VRAC and TRPM2 respectively."
35438288
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"Flufenamic acid and mefenamic acid inhibit NLRP3 inflammasome activation through the suppression of chloride efflux."
29021150
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"The fenamates, mefenamic acid and flufenamic acid, inhibit the NLRP3 inflammasome in rodent models [88]; however, the limited use of NSAIDs throughout pregnancy [82] has restricted their development as treatments for placental inflammation."
40260875
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"Both in vitro and in vivo studies have shown that Diclofenac and Mefenamic acid can suppress the activation of the NLRP3 inflammasome and decrease the production of Interleukin-1β (IL-1β) in mouse models of Alzheimer's disease [71]."
38356603
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"A few NLRP3 inflammasome inhibitors, including sulforaphane, isoliquiritigenin, beta-hydroxybutyrate (BHB), flufenamic acid, mefenamic acid, 3,4-methylenedioxy-beta-nitrostyrene (MNS), parthenolide, BAY 11-7082, INF39, and MCC950, have been developed, but there is no evidence showing that these compounds can specifically and directly inhibit NLRP3 itself."
29021150
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"While flufenamic, meclofenamic, and mefenamic acids were able to inhibit IL-1β release in iBMDMs under challenging for the NLRP3 pathway, flufenamic, and mefenamic acid were unable to inhibit IL-1β under NLRC4 and AIM2 challenge, suggesting these acid derivatives are specific to the NLRP3 pathway."
35754962
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"Various Cl - channel inhibitors, including 4,4 '-diisothiocyano-2,2 ' stilbene-disulfonic acid (DIDS), 5-nitro-(3-phenylpropylamino) benzoic acid (NPPB), flufenamic acid, mefenamic acid, and indanyloxyacetic acid 94 (IAA94), block the NLRP3 inflammasome but can not block the NLRC4 or AIM2 inflammasomes."
33603747
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"Different NLRP3 inflammasome inhibitors, including sulforaphane, β-hydroxybutyrate, glyburide, flufenamic acid, mefenamic acid, parthenolide, BAY 11-7082, INF39, and MCC950 have been developed, but there is no evidence demonstrating that these compounds directly and specifically target NLRP3 itself (212)."
30619282
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"319 Recent studies have shown that fenamic nonsteroidal anti‐inflammatory drugs such as flufenamic acid and mefenamic acid can inhibit cyclooxygenase to exert anti‐inflammatory effects and inhibit NLRP3 activation."
37125240
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"Studies have shown that, unlike other NSAIDs, fenamates (mefenamic acid, flufenamic acid) selectively inhibit the NLRP3 inflammasome and IL-1beta release via inhibiting the membrane volume regulated anion (Cl -) channel (VRAC), independent of its cyclooxygenase-1 (COX-1) mediated anti-inflammatory activity."
32574259
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"XREF_BIBR Cl - channel blockers such as mefenamic acid, flufenamic acid, benzoic acid, etc, can inhibit the NLRP3 activation."
33814921