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WNT11 binds FZD7. 36 / 38
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"Typical non canonical Wnt ligands such as WNT5A and WNT11 bind FZD7 and activate the planar cell polarity XREF_BIBR, XREF_BIBR or the Ca 2+ pathway XREF_BIBR, XREF_BIBR, shown to be involved in SCZ 46."
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"In contrast, PCP can be activated by accumulation of proteins at the plasma membrane—such is the case with Wnt11 signaling where it interacts with protein Fz7 to cause Dvl (Dsh) accumulation xref ."
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"For instance, the receptor-tyrosine kinases Ror2, Ryk and Ptk7 have previously been shown to functionally interact with Wnt11 and/or Fz7 in regulating non-canonical Wnt signaling ( xref ; xref ; xref ; xref ; xref ), pointing to the possibility that they might also be involved in mediating Wnt11 signaling within the ppl."
30648973
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"Wnt11 binds to Fzd7 and acts through the core transducer of PCP signal Dsh which in turn activates RhoA and Rok2 to modulate actin cytoskeleton (Djiane et al., 2000; Habas et al., 2003; Marlow et al., 2002; Tada & Smith, 2000)."
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"However, marginal cells activate noncanonical Wnt signaling (Wnt11-Fz7) locally and thus increase cell cohesion to counteract the effect of mitotic rounding on contact disassembly."
35115507
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"To detect interactions between Wnt11 and Fzd7, HEK293T cells were co-transfected with the respective pEX-3 vectors encoding Fzd7 ectodomain-HA and FLAG-tagged Wnt11 using X-tremeGENE HP DNA Transfecti[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
31150636
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"First, ectopic expression of celsr2 increases cell–cell contact persistency in cells of the zebrafish blastula and colocalizes with Wnt11-Fzd7 at cell–cell contact (Witzel et al., 2006)."
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"Mac-Tum crosstalk also showed significant induction of the Wnt-signaling pathway (Wnt11-FZD7 axis), whose role has remained unclear in NSCLC in vivo."
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"Fzd7 could be interacting with Wnt11 ( xref ; xref ; xref ) , or another wnt ligand such as Wnt3a ( xref ), Wnt6 ( xref ; xref , xref ) or Wnt8c ( xref ; xref ) during these stages of development."
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"The cohesion or solid-like behavior results from Wnt11-Fz7 signaling-dependent increase in actomyosin contractility which promotes E-cadherin-actin localization at cell–cell contact edges xref ."
35115507
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"Furthermore, co-IP results showed that Wnt11 interacts with transmembrane Fzd7 to transmit Wnt signaling in rLESCs."
31150636
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"Additionally, the biochemical and functional interaction between Wnt11 and Fzd7 was previously found to inhibit canonical Wnt signaling mediated by Wnt3a ( Uysal-Onganer and Kypta, 2012 )."
31150636
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"Altogether and combined with the results of nuclear accumulation of β-catenin and luciferase reporter assays, it was revealed that FN inhibits the canonical Wnt pathway via the interaction between Wnt[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
31150636
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"We find that Fz2 but not Ryk recruits Dvl to discrete domains on the plasma membrane, similar to previously reported Wnt11–Fz7 interactions ( xref ) and consistent with our working model that Wnt5–Ryk and Wnt5–Fz lead to distinct signaling outputs."
20660632
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"Interactions between Wnt11 and Fzd7 contribute to the activation of Rho family GTPases ( Yamanaka and Nishida, 2007 ) and affect multiple signaling pathways that activate several different protein kin[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
31150636
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"The gray values of different proteins were analyzed using NIH Image J 1.48V software.To detect interactions between Wnt11 and Fzd7, HEK293T cells were co-transfected with the respective pEX-3 vectors [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
31150636
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"Additionally, the biochemical and functional interaction between Wnt11 and Fzd7 was previously found to inhibit canonical Wnt signaling mediated by Wnt3a ( Uysal-Onganer and Kypta, 2012 )."
31150636
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"Altogether and combined with the results of nuclear accumulation of β-catenin and luciferase reporter assays, it was revealed that FN inhibits the canonical Wnt pathway via the interaction between Wnt[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
31150636
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"All these findings indicate that ROCK1 and ROCK2 are involved in signaling via RhoA after enhancing the interaction between Wnt11 and Fzd7 in FN-treated rLESCs."
31150636
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"For example, Choi et al. used CCCExplorer [ xref ] to identify new ligand-receptor interactions, including IL6-IL6R and WNT11-FZD7, between macrophages and tumor cells in non-small cell lung cancer (NSCLC)."
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"All these findings indicate that ROCK1 and ROCK2 are involved in signaling via RhoA after enhancing the interaction between Wnt11 and Fzd7 in FN-treated rLESCs.The precise role of ROCK in cell prolife[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
31150636
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"Fzd7 could be interacting with Wnt11, or another wnt ligand such as Wnt3a, Wnt6 or Wnt8c during these stages of development."
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"In fact, FN acting through Wnt11/Fzd7 complex subsequently activates ROCK1 and ROCK2, improving the proliferation of rLESCs [56]."
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"Therefore, we theorized that ROCK may promote rLESC proliferation by increasing Myc activity, which needs to be verified in the future.In conclusion, FN not only enhances rLESC proliferation but also [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Direct binding of Wnt11 to Fz7 may be required to trigger this accumulation, as we found that the C-terminally truncated inactive version of Wnt11 potentially lacking the binding site to Fz is not sufficient."
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"In the zebrafish, interaction of Wnt11, Fz7, Dvl, and Flamingo (Fmi) increases cell contact persistence at respective puncta, and E-cadherin adhesion is strengthened by Pk1a."
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"This spatiotemporal enrichment of PLD1 at the DMZ mediates translocalization of Dvl from the cytosol to the plasma membrane upon Wnt11-Fz7 activation."
26806705
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"In conclusion, FN not only enhances rLESC proliferation but also maintains stemness by promoting Wnt11 and Fzd7 interactions."
31150636
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"In Xenopus embryos, Ryk forms a complex with Wnt11 and Fz7 to cause the b-arrestin-2-mediated endocytosis of Dvl, which is necessary for CE (Kim et al., 2008)."
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"Wnt11 binds to Fzd7 and acts through the core transducer of PCP signal Dsh which in turn activates RhoA and Rok2 to modulate actin cytoskeleton (Djiane et al., 2000; Habas et al., 2003; Marlow et al., 2002; Tada & Smith, 2000)."
23140626
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"In sum, Wnt11-induced Fz7 accumulations are associated with a local increase in cell contact persistence, most likely reflecting stronger cell adhesion at these contact sites."
17130287
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"Direct binding of Wnt11 to Fz7 may be required to trigger this accumulation, as we found that the C-terminally truncated inactive version of Wnt11 potentially lacking the binding site to Fz (Slb/Wnt11 tx226 ; xref ) is not sufficient."
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"Fz7 can bind directly to Wnt11 43 and both constitutively active and dominant negative forms of Fz7 interfere with normal convergent extension movements."
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"PAPC and C-cadherin can each form separate complexes with Frizzled7 when it is bound to Wnt11, and both complexes can downregulate C-cadherin-based adhesion."
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"Wnt7a- and Wnt11-binding Frizzled-7 activates the downstream cascade of the WNT/planar cell polarity (PCP) signaling, which strongly influences the mechanism of cytoskeleton regulation, as described in Figure 4.Celsr1, Celsr2, and Celsr3 codifying for the Cadherin EGF LAG seven-pass G-type receptor 1, Ankrd6, Dvl1, and Prickle3 exhibited up-regulation (Table 2)."
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"Fz7 can bind directly to Wnt11 43 and both constitutively active and dominant negative forms of Fz7 interfere with normal convergent extension movemen[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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