IndraLab

Statements

WNT11 binds FZD7. 19 / 20
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reach
"Direct binding of Wnt11 to Fz7 may be required to trigger this accumulation, as we found that the C-terminally truncated inactive version of Wnt11 potentially lacking the binding site to Fz is not sufficient."
17130287
reach
"Typical non canonical Wnt ligands such as WNT5A and WNT11 bind FZD7 and activate the planar cell polarity XREF_BIBR, XREF_BIBR or the Ca 2+ pathway XREF_BIBR, XREF_BIBR, shown to be involved in SCZ 46."
29507296
sparser
"In sum, Wnt11-induced Fz7 accumulations are associated with a local increase in cell contact persistence, most likely reflecting stronger cell adhesion at these contact sites."
17130287
reach
"PAPC and C-cadherin can each form separate complexes with Frizzled7 when it is bound to Wnt11, and both complexes can downregulate C-cadherin-based adhesion."
24355988
reach
"Fzd7 could be interacting with Wnt11, or another wnt ligand such as Wnt3a, Wnt6 or Wnt8c during these stages of development."
29101100
sparser
"Fzd7 could be interacting with Wnt11 ( xref ; xref ; xref ) , or another wnt ligand such as Wnt3a ( xref ), Wnt6 ( xref ; xref , xref ) or Wnt8c ( xref ; xref ) during these stages of development."
29101100
sparser
"FN facilitated rLESC self-renewal by promoting Wnt11 and Fzd7 interaction."
31150636
sparser
"We find that Fz2 but not Ryk recruits Dvl to discrete domains on the plasma membrane, similar to previously reported Wnt11–Fz7 interactions ( xref ) and consistent with our working model that Wnt5–Ryk and Wnt5–Fz lead to distinct signaling outputs."
20660632
reach
"FN facilitated rLESC self-renewal by promoting Wnt11 and Fzd7 interaction."
31150636
signor
"Consistent with this, xfz7 biochemically and functionally interacts with xwnt11"
10862746
sparser
"However, marginal cells activate noncanonical Wnt signaling (Wnt11-Fz7) locally and thus increase cell cohesion to counteract the effect of mitotic rounding on contact disassembly."
35115507
sparser
"Direct binding of Wnt11 to Fz7 may be required to trigger this accumulation, as we found that the C-terminally truncated inactive version of Wnt11 potentially lacking the binding site to Fz (Slb/Wnt11 tx226 ; xref ) is not sufficient."
17130287
sparser
"The cohesion or solid-like behavior results from Wnt11-Fz7 signaling-dependent increase in actomyosin contractility which promotes E-cadherin-actin localization at cell–cell contact edges xref ."
35115507
sparser
"For instance, the receptor-tyrosine kinases Ror2, Ryk and Ptk7 have previously been shown to functionally interact with Wnt11 and/or Fz7 in regulating non-canonical Wnt signaling ( xref ; xref ; xref ; xref ; xref ), pointing to the possibility that they might also be involved in mediating Wnt11 signaling within the ppl."
30648973
reach
"In the zebrafish, interaction of Wnt11, Fz7, Dvl, and Flamingo (Fmi) increases cell contact persistence at respective puncta, and E-cadherin adhesion is strengthened by Pk1a."
25778923
sparser
"Fz7 can bind directly to Wnt11 43 and both constitutively active and dominant negative forms of Fz7 interfere with normal convergent extension movemen[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12137734
sparser
"In contrast, PCP can be activated by accumulation of proteins at the plasma membrane—such is the case with Wnt11 signaling where it interacts with protein Fz7 to cause Dvl (Dsh) accumulation xref ."
29449961
reach
"When PAPC was part of a Wnt-11 and Fz7 complex, its Dynamin1- and clathrin dependent internalization was blocked."
22908314
reach
"Fz7 can bind directly to Wnt11 43 and both constitutively active and dominant negative forms of Fz7 interfere with normal convergent extension movements."
12137734