Other Services

This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

TSC2 phosphorylated on T1462 inhibits MTOR. 1 / 1

| 1

➶

reach

"Upon activation, AKT not only activates mTOR signaling by direct phosphorylation at Ser2448 of mTOR but also catalyzes phosphorylation at Thr1462 of TSC2 that inhibits TSC1/TSC2 complexes, a master negative regulator of mTOR (148, 149)."

34671561

Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...