IndraLab
Statements
"Expression of CA-PI3K caused a significant increase in membrane-associated Tiam1 (Fig. 5B), whereas expression of DN-PI3K caused increased cytosolic Tiam1 (Fig. 5A). CS did not affect the distribution of Tiam1 when either CA-PI3K or DN-PI3K was expressed. We also found that treatment with the Tiam1 inhibitor NSC23766 caused increased cytosolic localization of Tiam1, decreased Rac1 activity, and decreased cell migration"