IndraLab

Statements

TIAM1 activates RAC1. 2 / 2
2 |
bel
"Phosphatidylinositol 3-kinase (PI3K) is recruited to the membrane by intact E-cadherin adhesion junctions, where it generates phosphatidylinositol-(3,4,5)- triphosphate (PIP3), resulting in the activation of the RHO-GEF TIAM1 and subsequently of RAC1 and CDC42."
14964308
bel
"Expression of CA-PI3K caused a significant increase in membrane-associated Tiam1 (Fig. 5B), whereas expression of DN-PI3K caused increased cytosolic Tiam1 (Fig. 5A). CS did not affect the distribution of Tiam1 when either CA-PI3K or DN-PI3K was expressed. We also found that treatment with the Tiam1 inhibitor NSC23766 caused increased cytosolic localization of Tiam1, decreased Rac1 activity, and decreased cell migration"
20018857