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EGF leads to the phosphorylation of AKT1. 18 / 18
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"The induction of AKT1 and GSK-3β phosphorylation by EGF can be suppressed by the inhibition of Ca 2+ /CaM signaling [ xref ]."
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"Treatment with AKT inhibitor VIII suppressed EGF stimulated AKT1 phosphorylation in both cell lines, while having no significant effect on the phosphorylation of MEK1."
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"Here, disrupting lipid rafts by two different agents, MβCD and Filipin, a polyene macrolide that binds cholesterol, decreases EGF-induced Akt1 phosphorylation and the level of the anti-apoptotic prote[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"As EGF stimulation elicited AKT1 phosphorylation and altered the subcellular localisation of amino-terminal huntingtin in both StHdh Q111 and primary Hdh Q111 cell lines, we sought to investigate whether the phosphorylation of AKT1 may be a mechanism that regulates huntingtin subcellular localisation."
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"Interestingly, EGF triggers AKT1 phosphorylation via more rapid kinetics than those induced by androgens; this was recently documented by studies on the sensitivity of EGFR family proteins to disruptions in cholesterol synthesis and homeostasis, supporting the functional significance of EGF signal transduction through lipid rafts."
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"As kinase activation and inhibition has previously been associated with the regulation of the subcellular localisation of huntingtin [XREF_BIBR - XREF_BIBR], we investigated whether the differential responses in AKT1 and MEK1 phosphorylation following EGF stimulation could be reflected in the subcellular localisation of huntingtin."
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"EGF Treatment Upregulates Akt1 Phosphorylation in MED Rats."
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"Previous studies indicated that EGF activated phosphatidylinositol 3‐kinase (PI3K). xref PI3K is able to phosphorylate AKT1, thus in turn activating cyclin D1 pathway. xref , xref The data presented here show that EGF indeed increased AKT1 phosphorylation without affecting total AKT1 protein levels (Figure  xref )."
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"Although Akt1 phosphorylation changes induced by EGF are more rapid than those induced by R1881, the raft and non-raft compartments again are distinct from each other."
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"XREF_BIBR Gefitinib, the most effective EGFR inhibitor, efficiently blocked epidermal growth factor (EGF)-stimulated phosphorylation of EGFR, reduced phosphorylation of both MAPK and protein kinase B (AKT), and induced G1 arrest in the TNBC cells."
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"Resveratrol inhibited Akt-1 phosphorylation by EGF without affecting the amount of total Akt protein ( Fig. 4 A)."
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"Intriguingly, exogenous EGF did not further increase AKT1 phosphorylation ( xref ), suggesting that the constitutively hyper activated AKT pathway in VR cells is not amenable to additional significant activation by EGFR stimulation ( xref , xref ), similarly to what reported in the literature in other settings ( xref – xref )."
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"While EGF stimulated the phosphorylation of both AKT1 and AKT2 during the interphase, EGF only stimulated the phosphorylation of AKT2 in mitosis ( Fig. 4 C–E)."
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"It was shown that filipin prevented constitutive and EGF stimulated phosphorylation of Akt1, explaining its ability to induce apoptosis and prevent EGF mediated survival."
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"EGF-induced Akt1 phosphorylation was substantially reduced in a dose- and time-dependent manner in the caveolin-negative human prostate cancer cell line LnCaP, when treated with the raft-disrupting ag[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Authors reported that both Ang II and EGF could increase the phosphorylation of EGFR and protein kinase B (AKT) / ERK causing cell hypertrophy in H9c2 cells."
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"As shown in Figure  xref , EGF concentration‐dependently increased phosphorylation of AKT1 without affecting total AKT1 level (Figure  xref )."
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"While EGF stimulated the phosphorylation of both AKT1 and AKT2 during the interphase, EGF only stimulated the phosphorylation of AKT2 in mitosis ( Fig. 4 C–E)."
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