IndraLab

Statements

EGF leads to the phosphorylation of AKT1. 10 / 10
| 7 3
sparser
"Previous studies indicated that EGF activated phosphatidylinositol 3‐kinase (PI3K). xref PI3K is able to phosphorylate AKT1, thus in turn activating cyclin D1 pathway. xref , xref The data presented here show that EGF indeed increased AKT1 phosphorylation without affecting total AKT1 protein levels (Figure  xref )."
32441057
reach
"As kinase activation and inhibition has previously been associated with the regulation of the subcellular localisation of huntingtin [XREF_BIBR - XREF_BIBR], we investigated whether the differential responses in AKT1 and MEK1 phosphorylation following EGF stimulation could be reflected in the subcellular localisation of huntingtin."
26660732
reach
"EGF Treatment Upregulates Akt1 Phosphorylation in MED Rats."
29044143
sparser
"As shown in Figure  xref , EGF concentration‐dependently increased phosphorylation of AKT1 without affecting total AKT1 level (Figure  xref )."
32441057
reach
"It was shown that filipin prevented constitutive and EGF stimulated phosphorylation of Akt1, explaining its ability to induce apoptosis and prevent EGF mediated survival."
18949068
reach
"Interestingly, EGF triggers AKT1 phosphorylation via more rapid kinetics than those induced by androgens; this was recently documented by studies on the sensitivity of EGFR family proteins to disruptions in cholesterol synthesis and homeostasis, supporting the functional significance of EGF signal transduction through lipid rafts."
18667687
reach
"Treatment with AKT inhibitor VIII suppressed EGF stimulated AKT1 phosphorylation in both cell lines, while having no significant effect on the phosphorylation of MEK1."
26660732
reach
"As EGF stimulation elicited AKT1 phosphorylation and altered the subcellular localisation of amino-terminal huntingtin in both StHdh Q111 and primary Hdh Q111 cell lines, we sought to investigate whether the phosphorylation of AKT1 may be a mechanism that regulates huntingtin subcellular localisation."
26660732
reach
"XREF_BIBR Gefitinib, the most effective EGFR inhibitor, efficiently blocked epidermal growth factor (EGF)-stimulated phosphorylation of EGFR, reduced phosphorylation of both MAPK and protein kinase B (AKT), and induced G1 arrest in the TNBC cells."
27799799
sparser
"The induction of AKT1 and GSK-3β phosphorylation by EGF can be suppressed by the inhibition of Ca 2+ /CaM signaling [ xref ]."
35163631