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KCNMA1 activates rottlerin. 6 / 6
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"However, the F273S and Delta3R mutant appeared to be exceptional which was inactive in BK channel modulation but still effective in attenuating the BK channel activating effect of mallotoxin, with a resultant DeltaV 1/2 (+/- mallotoxin) value of only 29mV."
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"Like the gamma1-WT subunit, they also largely suppressed the BK channel activating effect of mallotoxin, with nearly no noticeable shift in V 1/2 (| DeltaV 1/2 | < = 5mV) between the treated and untreated membrane patches."
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"The BK channel activating effect of mallotoxin was largely abolished when the gamma1 subunit was either endogenously expressed in salivary gland cells or heterologously expressed in human embryonic kidney (HEK) -293 cells XREF_BIBR."
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"Our observation that the gamma2 and gamma3 subunits also largely attenuated the BK channel activating effect of mallotoxin suggests that the pharmacological properties of BK channels exerted by the three different auxiliary gamma subunits are similar."
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"The BK channel activating effect of mallotoxin was not significantly attenuated by most of the loss-of-function mutants."
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"Their presence only partially antagonized the BK channel activating effect of mallotoxin, and the resultant DeltaV 1/2 (+/- mallotoxin) values were -44 mV, -34 mV, -30 mV, and -40 mV, respectively (XREF_FIG; XREF_TABLE), which are close to a line drawn between the effects of mallotoxin on the BKalpha channels and on the BKalphagamma1 WT channels (XREF_FIG; XREF_TABLE)."
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